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August 2011 Briefing - Pulmonology

August 2011 Briefing - Pulmonology

Here are what the editors at HealthDay consider to be the most important developments in Pulmonology for August 2011. This roundup includes the latest research news from journal articles, as well as the FDA approvals and regulatory changes that are the most likely to affect clinical practice.

Counseling Helps Smokers With Comorbid Disorders Quit

TUESDAY, Aug. 30 (HealthDay News) -- Counseling by primary care providers (PCPs) is effective for encouraging smoking cessation for individuals with and without alcohol, drug, or mental (ADM) disorders, according to a study published online Aug. 22 in Nicotine & Tobacco Research.

Abstract (http://ntr.oxfordjournals.org/content/early/2011/08/22/ntr.ntr167.short?rss=1/ )Full Text (subscription or payment may be required) (http://ntr.oxfordjournals.org/content/early/2011/08/22/ntr.ntr167.full.pdf+html/ )

Public Sector Funds Large Part of State Obesity-Related Costs

MONDAY, Aug. 29 (HealthDay News) -- Between 22 and 55 percent of U.S. state-level obesity-related costs are financed by the public sector via Medicare and Medicaid, according to a study published online June 16 in Obesity.

Abstract (http://www.nature.com/oby/journal/vaop/ncurrent/full/oby2011169a.html )Full Text (subscription or payment may be required) (hhttp://www.nature.com/oby/journal/vaop/ncurrent/full/oby2011169a.html )

Loss of Jobs Means Loss of Health Coverage for Many in U.S.

MONDAY, Aug. 29 (HealthDay News) -- For American adults who lose their health insurance coverage when they lose their jobs, the majority remain uninsured, delay getting needed health care or prescriptions, and report financial difficulties paying medical bills, according to a report published online Aug. 24 by The Commonwealth Fund.

Report (http://www.commonwealthfund.org/~/media/Files/Publications/Issue%20Brief/2011/Aug/1540_Doty_when_unemployed_means_uninsured_COBRA_reform%20brief.pdf )

Complementary Medicine Used More by Health Care Workers

FRIDAY, Aug. 26 (HealthDay News) -- U.S. health care workers, especially health care providers, are more likely to use complementary and alternative medicine (CAM) than the general, employed U.S. population, according to a study published online Aug. 22 in Health Services Research.

Abstract (http://onlinelibrary.wiley.com/doi/10.1111/j.1475-6773.2011.01304.x/abstract )Full Text (subscription or payment may be required) (http://onlinelibrary.wiley.com/doi/10.1111/j.1475-6773.2011.01304.x/pdf )

Pharmaceutical Ads Often Don't Adhere to U.S. FDA Guidelines

THURSDAY, Aug. 25 (HealthDay News) -- Physician-targeting pharmaceutical advertisements have low rates of adherence to U.S. Food and Drug Administration (FDA) guidelines and provide inadequate information for safe prescribing, according to a study published online Aug. 17 in PLoS One.

Full Text (subscription or payment may be required) (http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0023336#s2 )

CDC: State Preemption Rates Unchanged in Tobacco Efforts

THURSDAY, Aug. 25 (HealthDay News) -- The number of U.S. states that preempt local advertising restrictions and youth access restrictions to tobacco products appears to have remained unchanged, according to a report in the August 26 issue of the Centers for Disease Control and Prevention (CDC)'s Morbidity and Mortality Weekly Report.

Full Text (http://www.cdc.gov/mmwr/preview/mmwrhtml/mm6033a2.htm?s_cid=mm6033a2_w )

Socioeconomic Status, Gender Affect Cystic Fibrosis Survival

THURSDAY, Aug. 25 (HealthDay News) -- For patients with cystic fibrosis, socioeconomic status and gender remained constant, strong predictors of survival above the annual median age at death from 1959 to 2008, according to a study published online Aug. 24 in the BMJ.

Abstract (http://www.bmj.com/content/343/bmj.d4662 )Full Text (http://www.bmj.com/content/343/bmj.d4662.full.pdf )Editorial (subscription or payment may be required) (http://www.bmj.com/content/343/bmj.d4818 )

Parasitic Co-infection Impairs TB Resistance in Mice

THURSDAY, Aug. 25 (HealthDay News) -- Infection with Nippostrongylus brasiliensis (Nb) transiently impairs resistance to Mycobacterium tuberculosis (Mtb) in mice, according to an experimental study published online Aug. 8 in the Journal of Experimental Medicine.

Abstract (http://jem.rupress.org/content/early/2011/08/03/jem.20091473.abstract )Full Text (subscription or payment may be required) (http://jem.rupress.org/content/early/2011/08/03/jem.20091473.full )

Helium Lung Morphometry Sensitive to Emphysema Changes

THURSDAY, Aug. 25 (HealthDay News) -- In patients with chronic obstructive pulmonary disease (COPD), non-invasive helium 3 (3He) lung morphometry is more sensitive in identifying in vivo early emphysematous changes in alveolar geometry than low-dose computed tomography (CT) or traditional pulmonary function testing (PFT), according to a study published online July 6 in Radiology.

Abstract (http://radiology.rsna.org/content/260/3/866.abstract )Full Text (subscription or payment may be required) (http://radiology.rsna.org/content/260/3/866.full )

Azithromycin Decreases COPD Exacerbation Frequency

WEDNESDAY, Aug. 24 (HealthDay News) -- In selected patients with chronic obstructive pulmonary disorder (COPD), daily azithromycin for one year together with usual treatment decreases the frequency of exacerbations but increases the frequency of hearing decrements, according to a study published Aug. 25 in the New England Journal of Medicine.

Full Text (subscription or payment may be required) (http://www.nejm.org/doi/full/10.1056/NEJMoa1104623?query=featured_home )Editorial (subscription or payment may be required) (http://www.nejm.org/doi/full/10.1056/NEJMe1106979?query=featured_home )

Hospitalization Ups Unintentional Discontinuation of Meds

TUESDAY, Aug. 23 (HealthDay News) -- Hospital or intensive care unit (ICU) admission is associated with unintentional discontinuation of medication for chronic diseases, according to a study published online Aug. 23 in the Journal of the American Medical Association.

Abstract (http://jama.ama-assn.org/content/306/8/840.short )Full Text (subscription or payment may be required) (http://jama.ama-assn.org/content/306/8/840.full.pdf+html )Editorial (subscription or payment may be required) (http://jama.ama-assn.org/content/306/8/878.short )

Persistent Asthma Tied to In Utero Smoke Exposure

TUESDAY, Aug. 23 (HealthDay News) -- In utero tobacco smoke exposure is significantly associated with development of persistent asthma in Mexican, Puerto Rican, and black children, according to a study published online Aug. 22 in Pediatrics.

Abstract (http://pediatrics.aappublications.org/content/early/2011/08/17/peds.2011-0640.abstract )Full Text (subscription or payment may be required) (http://pediatrics.aappublications.org/content/early/2011/08/17/peds.2011-0640.full.pdf+html )

Pre-Pregnancy Weight Tied to Adolescent Asthma Risk

MONDAY, Aug. 22 (HealthDay News) -- Maternal pre-pregnancy weight and obesity is associated with an increase in asthma symptoms in adolescents, according to a study published online Aug. 15 in issue of Journal of Epidemiology & Community Health.

Abstract (http://jech.bmj.com/content/early/2011/07/08/jech.2011.133777.abstract )Full Text (subscription or payment may be required) (http://jech.bmj.com/content/early/2011/07/08/jech.2011.133777.full )

Polymorphisms Tied to Smoking Behavior Up Lung Cancer Risk

MONDAY, Aug. 22 (HealthDay News) -- Genetic variations in the CYP2A6 and CHRNA5-CHRNA3-CHRNB4 (CHRNA5-A3-B4) genes are together associated with an increase in cigarette consumption and nicotine dependence, and can independently and additively increase lung cancer risk, according to a study published online July 11 in the Journal of the National Cancer Institute.

Abstract (http://jnci.oxfordjournals.org/content/early/2011/07/10/jnci.djr237.abstract )Full Text (subscription or payment may be required) (http://jnci.oxfordjournals.org/content/early/2011/07/10/jnci.djr237.full )

Dalteparin Sodium Effective, Safe in Upper-Extremity DVT

MONDAY, Aug. 22 (HealthDay News) -- Patients with upper-extremity deep-vein thrombosis (DVT) may be treated safely with either dalteparin sodium followed by warfarin or dalteparin sodium monotherapy for three months with a successful outcome, according to a study published online Aug. 12 in the Journal of Thrombosis and Haemostasis.

Abstract (http://onlinelibrary.wiley.com/doi/10.1111/j.1538-7836.2011.04466.x/abstract )Full Text (subscription or payment may be required) (http://onlinelibrary.wiley.com/doi/10.1111/j.1538-7836.2011.04466.x/pdf )

CDC: Legionellosis Incidence Up During 2000 to 2009

FRIDAY, Aug. 19 (HealthDay News) -- The incidence of reported legionellosis in the United States almost tripled between 2000 and 2009; however, the reason for the increase remains unclear, according to a report in the Aug. 19 issue of the U.S. Centers for Disease Control and Prevention's Morbidity and Mortality Weekly Report.

Full Text (http://www.cdc.gov/mmwr/preview/mmwrhtml/mm6032a3.htm?s_cid=mm6032a3_w )

Budesonide Ups Expression of GILZ and FKBP51 in Asthma

FRIDAY, Aug. 19 (HealthDay News) -- Treatment with inhaled budesonide increases the expression of GILZ and FKBP51 in patients with atopic asthma, according to a study published online Aug. 9 in the British Journal of Pharmacology.

Abstract (http://onlinelibrary.wiley.com/doi/10.1111/j.1476-5381.2011.01620.x/abstract )Full Text (subscription or payment may be required) (http://onlinelibrary.wiley.com/doi/10.1111/j.1476-5381.2011.01620.x/full )

CDC: 2010/2011 Flu Vaccination Coverage Studied

THURSDAY, Aug. 18 (HealthDay News) -- Influenza vaccination coverage among health care personnel (HCP) and pregnant women in the 2010/2011 influenza season was similar to coverage for the 2009/2010 season, according to two reports in the Aug. 19 issue of the U.S. Centers for Disease Control and Prevention's Morbidity and Mortality Weekly Report.

Full Text - Health Care Personnel (http://www.cdc.gov/mmwr/preview/mmwrhtml/mm6032a1.htm?s_cid=mm6032a1_w )Full Text - Pregnant Women (http://www.cdc.gov/mmwr/preview/mmwrhtml/mm6032a2.htm?s_cid=mm6032a2_w )

Sniffer Dogs May Be Used to Detect Lung Cancer

THURSDAY, Aug. 18 (HealthDay News) -- Sniffer dogs may be used for the early detection of lung cancer, according to a study published online Aug. 18 in the European Respiratory Journal.

Abstract (http://erj.ersjournals.com/content/early/2011/08/05/09031936.00051711.abstract?sid=3d0ee4ad-1eea-472a-a618-383fdfc01db5 )Full Text (subscription or payment may be required) (http://erj.ersjournals.com/content/early/2011/08/05/09031936.00051711.full.pdf+html )

Majority of DVT Cases After Surgery Linked to Catheter Use

THURSDAY, Aug. 18 (HealthDay News) -- Following general surgical operations, the incidence of deep venous thrombosis (DVT) is low, but more than 60 percent of cases are catheter-induced, according to a study published online Aug. 15 in the Archives of Surgery.

Abstract (http://archsurg.ama-assn.org/cgi/content/short/archsurg.2011.204 )Full Text (subscription or payment may be required) (http://archsurg.ama-assn.org/cgi/content/full/archsurg.2011.204 )

High Cumulative Malpractice Risk for All Physicians

THURSDAY, Aug. 18 (HealthDay News) -- Physicians in all specialties have a high cumulative risk of facing a malpractice claim by age 65; although most claims do not lead to indemnity payments, according to a study published in the Aug. 18 issue of the New England Journal of Medicine.

Abstract (http://www.nejm.org/doi/full/10.1056/NEJMsa1012370 )Full Text (http://www.nejm.org/doi/full/10.1056/NEJMsa1012370#t=article )

Bordetella Infections Rare in Children With Cough Illness

TUESDAY, Aug. 16 (HealthDay News) -- Bordetella pertussis (B. pertussis) and Bordetella parapertussis (B. parapertussis) infections are rarely found in young patients with cough illness, as are concomitant virus/Bordetella infections, according to a study published in the August issue of the Pediatric Infectious Disease Journal.

Abstract (http://journals.lww.com/pidj/Abstract/2011/08000/Bordetella_pertussis_and_Concomitant_Viral.3.aspx )Full Text (subscription or payment may be required) (http://journals.lww.com/pages/login.aspx?ReturnUrl=%2fpidj%2fsecure%2fpages%2fpurchase.aspx%3fan%3d00006454-201108000-00003 )

Patient Care Improves With Anticoagulation Service

TUESDAY, Aug. 16 (HealthDay News) -- A Pharmacist-Directed Anticoagulation Service (PDAS) improves the quality of care for patients taking the anticoagulant drug warfarin in an inpatient setting by coordinating the transition of care from an inpatient to an outpatient setting, according to a study published online Aug. 10 in the Journal of Hospital Medicine.

Abstract (http://onlinelibrary.wiley.com/doi/10.1002/jhm.910/abstract )Full Text (subscription or payment may be required) (http://onlinelibrary.wiley.com/doi/10.1002/jhm.910/full )

Sleep Apnea Recurs Within Days of CPAP Withdrawal

MONDAY, Aug. 15 (HealthDay News) -- In patients with obstructive sleep apnea (OSA) on continuous positive airway pressure (CPAP), withdrawal of CPAP is associated with rapid recurrence of OSA and subjective sleepiness, according to a study published online Aug. 11 in the American Journal of Respiratory and Critical Care Medicine.

Abstract (http://ajrccm.atsjournals.org/cgi/content/abstract/201106-0964OCv1 )Full Text (subscription or payment may be required) (http://ajrccm.atsjournals.org/cgi/reprint/201106-0964OCv1 )

Predictors of Survival After Cardiac Arrest in ICU Identified

MONDAY, Aug. 15 (HealthDay News) -- Independent predictors of survival following cardiac arrest which occurs in the intensive care unit (ICU) include the presenting rhythm, age, and duration of cardiopulmonary resuscitation (CPR), according to a study published online Aug. 15 in CMAJ, the Journal of the Canadian Medical Association.

Abstract (http://www.cmaj.ca/content/early/2011/08/15/cmaj.100034 )Full Text (http://www.cmaj.ca/content/early/2011/08/15/cmaj.100034.full.pdf+html )Editorial (subscription or payment may be required) (http://www.cmaj.ca/content/early/2011/08/15/cmaj.110982 )

Maternal Asthma Ups Risk of Perinatal Complications

MONDAY, Aug. 15 (HealthDay News) -- Maternal asthma is associated with an increased risk of adverse perinatal outcomes, including increased risk of low birth weight, small for gestational age (SGA), preterm labor and delivery, and preeclampsia, according to a meta-analysis published online July 13 in BJOG: An International Journal of Obstetrics and Gynaecology.

Abstract (http://onlinelibrary.wiley.com/doi/10.1111/j.1471-0528.2011.03055.x/abstract )Full Text (subscription or payment may be required) (http://onlinelibrary.wiley.com/doi/10.1111/j.1471-0528.2011.03055.x/full )

Compression Stockings Lessen Obstructive Sleep Apnea

FRIDAY, Aug. 12 (HealthDay News) -- In patients with obstructive sleep apnea (OSA) and chronic venous insufficiency (CVI), wearing compression stockings during the day attenuates OSA by reducing fluid accumulation in the legs and its overnight redistribution into the neck, according to a study published online Aug. 11 in the American Journal of Respiratory and Critical Care Medicine.

Abstract (http://ajrccm.atsjournals.org/cgi/content/abstract/201102-0350OCv1 )Full Text (subscription or payment may be required) (http://ajrccm.atsjournals.org/cgi/reprint/201102-0350OCv1 )

tPA, DNase Improves Fluid Drainage in Pleural Infection

THURSDAY, Aug. 11 (HealthDay News) -- Combined intrapleural tissue plasminogen activator (t-PA) and DNase therapy improves fluid drainage in patients with pleural infection and reduces hospital stay duration and the frequency of surgical referral, according to a study published in the Aug. 11 issue of the New England Journal of Medicine.

Full Text (subscription or payment may be required) (http://www.nejm.org/doi/full/10.1056/NEJMoa1012740 )

Sleep-Disordered Breathing Tied to Dementia in Older Women

TUESDAY, Aug. 9 (HealthDay News) -- Older women with sleep-disordered breathing have an increased risk of cognitive impairment and dementia, according to a study published in the Aug. 10 issue of the Journal of the American Medical Association.

Abstract (http://jama.ama-assn.org/content/306/6/613.short )Full Text (http://jama.ama-assn.org/content/306/6/613.full )Editorial (subscription or payment may be required) (http://jama.ama-assn.org/content/306/6/654.extract )

V600E BRAF Mutations Indicate Poor Prognosis in NSCLC

TUESDAY, Aug. 9 (HealthDay News) -- In patients with non-small-cell lung cancer (NSCLC), V600E BRAF mutations are more common in women and are associated with aggressive tumor histology and poor prognosis, according to a study published online Aug. 8 in the Journal of Clinical Oncology.

Abstract (http://jco.ascopubs.org/content/early/2011/08/08/JCO.2011.35.9638.abstract )Full Text (subscription or payment may be required) (http://jco.ascopubs.org/content/early/2011/08/08/JCO.2011.35.9638.full.pdf+html )

Doublet Chemo Improves Survival in Elderly With NSCLC

TUESDAY, Aug. 9 (HealthDay News) -- Despite more toxic effects, doublet chemotherapy with carboplatin and weekly paclitaxel is associated with significantly higher survival benefits than monotheraphy with either vinorelbine or gemcitabine in elderly patients with advanced non-small-cell lung cancer (NSCLC), according to a study published online Aug. 9 in The Lancet.

Abstract (http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(11)60780-0/abstract )Full Text (subscription or payment may be required) (http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(11)60780-0/fulltext )Editorial (subscription or payment may be required) (http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(11)61259-2/fulltext )

AHRQ: CPAP Highly Effective in Treating Obstructive Sleep Apnea

MONDAY, Aug. 8 (HealthDay News) -- Continuous positive airway pressure (CPAP) machines and mandibular advancement devices (MADs) are very effective in treating obstructive sleep apnea (OSA), but evidence supporting weight loss or surgery is not as strong, according to a report published Aug. 8 by the Agency for Healthcare Research and Quality (AHRQ).

More Information (http://www.effectivehealthcare.ahrq.gov/index.cfm/search-for-guides-reviews-and-reports/?pageaction=displayproduct&productid=731 )

Short Time to First Cigarette Ups Head and Neck Cancer Risk

MONDAY, Aug. 8 (HealthDay News) -- Smoking the first cigarette of the day within 60 minutes of waking increases the risk of head and neck cancer and of lung cancer, according to two studies published online Aug. 8 in Cancer.

Abstract - Muscat 1 (http://onlinelibrary.wiley.com/doi/10.1002/cncr.26235/abstract )Full Text (subscription or payment may be required) (http://onlinelibrary.wiley.com/doi/10.1002/cncr.26235/full )Abstract - Muscat 2 (http://onlinelibrary.wiley.com/doi/10.1002/cncr.26236/abstract )Full Text (subscription or payment may be required) (http://onlinelibrary.wiley.com/doi/10.1002/cncr.26236/full )

Cost of Interacting With Payers Higher in U.S. Than Canada

FRIDAY, Aug. 5 (HealthDay News) -- Physician practices in the United States spend considerably more on interactions with health plans than Canadian practices, according to a study published in the August issue of Health Affairs.

Abstract (http://content.healthaffairs.org/content/early/2011/08/03/hlthaff.2010.0893.abstract )Full Text (subscription or payment may be required) (http://content.healthaffairs.org/content/early/2011/08/03/hlthaff.2010.0893.full )

Quantitative CT IDs Lung Changes Tied to COPD Exacerbations

THURSDAY, Aug. 4 (HealthDay News) -- Greater lung emphysema and airway wall thickness on quantitative computed tomography (CT) are associated with chronic obstructive pulmonary disease (COPD) exacerbations independent of the severity of airflow obstruction, according to a study published online July 25 in Radiology.

Abstract (http://radiology.rsna.org/content/early/2011/07/19/radiol.11110173.abstract )Full Text (subscription or payment may be required) (http://radiology.rsna.org/content/early/2011/07/19/radiol.11110173.full )

Lebrikizumab Ups Lung Function in Adults With Asthma

THURSDAY, Aug. 4 (HealthDay News) -- Treatment with lebrikizumab increases lung function in adults with asthma, especially for those with high levels of serum periostin, according to a study published online Aug. 3 in the New England Journal of Medicine.

Abstract (http://www.nejm.org/doi/full/10.1056/NEJMoa1106469?query=featured_home )Full Text (http://www.nejm.org/doi/full/10.1056/NEJMoa1106469?query=featured_home#t=article )

Prenatal Magnetic Field Exposure Ups Children's Asthma Risk

WEDNESDAY, Aug. 3 (HealthDay News) -- Maternal exposure to high levels of magnetic fields (MFs) during pregnancy is associated with increased asthma risk in the offspring, according to a study published online Aug. 1 in the Archives of Pediatrics & Adolescent Medicine.

Abstract (http://archpedi.ama-assn.org/cgi/content/short/archpediatrics.2011.135 )Full Text (subscription or payment may be required) (http://archpedi.ama-assn.org/cgi/content/full/archpediatrics.2011.135 )

Oseltamivir-Resistant Pandemic H1N1 2009 Virus Emerging

WEDNESDAY, Aug. 3 (HealthDay News) -- Clinicians should be aware of an emergence of oseltamivir-resistant pandemic H1N1 2009 virus, particularly in immunocompromised patients, according to a study published online July 29 in the U.S. Centers for Disease Control and Prevention's Emerging Infectious Diseases.

Full Text (http://www.cdc.gov/eid/content/17/10/pdfs/11-0117.pdf )

Pneumothorax Common After Transthoracic Needle Biopsy

TUESDAY, Aug. 2 (HealthDay News) -- Transthoracic needle lung biopsy of a pulmonary nodule is rarely complicated by hemorrhage, but there is a higher risk of pneumothorax that often requires chest tube placement, according to a study published in the Aug. 2 issue of the Annals of Internal Medicine.

Abstract (http://www.annals.org/content/155/3/137.abstract )Full Text (subscription or payment may be required) (http://www.annals.org/content/155/3/137.full )

New Guidelines Issued for COPD Diagnosis, Management

TUESDAY, Aug. 2 (HealthDay News) -- Clinicians should use spirometry for screening or diagnosis, and inhaled therapies, pulmonary rehabilitation programs, and supplemental oxygen therapy to improve management of chronic obstructive pulmonary disorder (COPD), according to the joint practice guidelines of the American College of Physicians (ACP), the American College of Chest Physicians, the American Thoracic Society, and the European Respiratory Society, published in the Aug. 2 issue of the Annals of Internal Medicine.

Abstract (http://www.annals.org/content/155/3/179.abstract )Full Text (subscription or payment may be required) (http://www.annals.org/content/155/3/179.full )