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January 2013 Briefing - Pathology

January 2013 Briefing - Pathology

Here are what the editors at HealthDay consider to be the most important developments in Pathology for January 2013. This roundup includes the latest research news from journal articles, as well as the FDA approvals and regulatory changes that are the most likely to affect clinical practice.

Peds Rotavirus Vaccine Offers Indirect Protection for Adults

THURSDAY, Jan. 31 (HealthDay News) -- Pediatric rotavirus vaccinations also decrease the prevalence of the disease in unvaccinated adults, according to a study published online Jan. 23 in Clinical Infectious Diseases.

Abstract (http://cid.oxfordjournals.org/content/early/2013/01/09/cid.cis1010.abstract )Full Text (subscription or payment may be required) (http://cid.oxfordjournals.org/content/early/2013/01/09/cid.cis1010.full )

Single, Fractional Dose of Polio Vaccine Induces Priming

WEDNESDAY, Jan. 30 (HealthDay News) -- Priming immune responses are induced in most infants after vaccination with a single dose of inactivated poliovirus vaccine (IPV), according to a study published in the Jan. 31 issue of the New England Journal of Medicine.

Full Text (subscription or payment may be required) (http://www.nejm.org/doi/full/10.1056/NEJMoa1202541?query=featured_home )

Sclerostin Linked to Vascular Disease in Type 2 Diabetes

MONDAY, Jan. 28 (HealthDay News) -- Circulating levels of the Wnt/β-catenin signaling inhibitor sclerostin are higher in patients with type 2 diabetes who also have atherosclerotic disease, according to a study published online Jan. 3 in Diabetes Care.

Abstract (http://care.diabetesjournals.org/content/early/2013/01/03/dc12-1691.abstract )Full Text (subscription or payment may be required) (http://care.diabetesjournals.org/content/early/2013/01/03/dc12-1691.full.pdf+html )

Folic Acid Supplementation Has No Effect on Cancer Incidence

FRIDAY, Jan. 25 (HealthDay News) -- Folic acid supplementation has no effect on the risk of cancer in the first five years of treatment, according to a meta-analysis published online Jan. 25 in The Lancet.

Abstract (http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(12)62001-7/abstract )Full Text (subscription or payment may be required) (http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(12)62001-7/fulltext )Editorial (subscription or payment may be required) (http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(13)60110-5/fulltext )

Lung Cancer Death Risk in Female Smokers Has Risen

WEDNESDAY, Jan. 23 (HealthDay News) -- Although female smokers had a lower risk of dying of lung cancer than male smokers through the 1980s, male and female smokers now have similar risks of dying from lung cancer and other causes, according to a study published in the Jan. 24 issue of the New England Journal of Medicine.

Abstract (http://www.nejm.org/doi/full/10.1056/NEJMsa1211127 )Full Text (http://www.nejm.org/doi/full/10.1056/NEJMsa1211127#t=article )Editorial (http://www.nejm.org/doi/full/10.1056/NEJMe1213751 )

Interactive Decision Support System Ups Breast CA Detection

MONDAY, Jan. 21 (HealthDay News) -- Compared with currently used computer-aided detection (CAD) prompts, use of an interactive CAD system, in which CAD marks and their associated suspiciousness scores remain hidden unless queried by a reader, improves the detection of malignant masses using digital mammography, according to research published in the January issue of Radiology.

Abstract (http://radiology.rsna.org/content/266/1/123.abstract )Full Text (subscription or payment may be required) (http://radiology.rsna.org/content/266/1/123.full )

Ulcerative Colitis, Not Crohn's, Deaths Down From 1982

MONDAY, Jan. 21 (HealthDay News) -- Over the past 30 years in Denmark, mortality from ulcerative colitis (UC) has decreased, but mortality from Crohn's disease (CD) has remained persistently higher than the general population, according to research published in the January issue of Clinical Gastroenterology and Hepatology.

Abstract (http://www.cghjournal.org/article/S1542-3565(12)01141-X/abstract )Full Text (http://www.cghjournal.org/article/S1542-3565(12)01141-X/fulltext )

About 10 Percent of Neoplastic Polyps Incompletely Resected

FRIDAY, Jan. 18 (HealthDay News) -- About 10 percent of neoplastic polyps are incompletely resected, with considerable variation in the rate of incomplete resection between endoscopists, according to a study published in the January issue of Gastroenterology.

Abstract (http://www.gastrojournal.org/article/S0016-5085(12)01443-6/abstract )Full Text (http://www.gastrojournal.org/article/S0016-5085(12)01443-6/fulltext )Editorial (http://www.gastrojournal.org/article/S0016-5085(12)01659-9/fulltext )

Expression, Genomic Patterns Predict Sarcoma Progression

FRIDAY, Jan. 18 (HealthDay News) -- The Complexity Index in Sarcoma (CINSARC) and Genomic Index prognostic signatures are valid independent methods of assessing synovial sarcoma (SS) prognosis, according to a study published online Jan. 14 in the Journal of Clinical Oncology.

Abstract (http://jco.ascopubs.org/content/early/2013/01/08/JCO.2012.46.0147.abstract )Full Text (subscription or payment may be required) (http://jco.ascopubs.org/content/early/2013/01/08/JCO.2012.46.0147.full.pdf+html )

Efforts Failed to Up Primary Care, Rural Resident Training

FRIDAY, Jan. 18 (HealthDay News) -- The 2005 redistribution of graduate medical education (GME) funds did little to train more residents in primary care and in rural areas, according to a study published in the January issue of Health Affairs.

Abstract (http://content.healthaffairs.org/content/32/1/102.abstract )Full Text (subscription or payment may be required) (http://content.healthaffairs.org/content/32/1/102.full )

Case Study IDs B. miyamotoi As Cause of Meningoencephalitis

THURSDAY, Jan. 17 (HealthDay News) -- The spirochete, Borrelia miyamotoi, may be an underrecognized cause of meningoencephalitis, according to a case study published in the Jan. 17 issue of the New England Journal of Medicine.

Full Text (subscription or payment may be required) (http://www.nejm.org/doi/full/10.1056/NEJMoa1209039 )Letter to the Editor (http://www.nejm.org/doi/full/10.1056/NEJMc1215469 )

Inhibitor Development Risk Similar for Factor VIII Products

THURSDAY, Jan. 17 (HealthDay News) -- For children with severe hemophilia A, the risk of inhibitor development is similar with plasma-derived and recombinant factor VIII products and is not affected by von Willebrand factor content or by switching among products, according to research published in the Jan. 17 issue of the New England Journal of Medicine.

Full Text (subscription or payment may be required) (http://www.nejm.org/doi/full/10.1056/NEJMoa1208024 )

Tamoxifen Shows Pre-Clinical Potential in Muscular Dystrophy

THURSDAY, Jan. 17 (HealthDay News) -- The breast cancer drug tamoxifen improves muscle strength and function in a mouse model of Duchenne muscular dystrophy (DMD), according to a study published online Jan. 15 in The American Journal of Pathology.

Abstract (http://www.sciencedirect.com/science/article/pii/S0002944012008127 )Full Text (subscription or payment may be required) (http://www.sciencedirect.com/science/article/pii/S0002944012008127 )

Donor Fecal Infusion Effective for C. difficile Infection

WEDNESDAY, Jan. 16 (HealthDay News) -- Duodenal infusions of donor feces are significantly more effective than vancomycin for treating recurrent Clostridium difficile infections, according to a study published online Jan. 16 in the New England Journal of Medicine.

Abstract (http://www.nejm.org/doi/full/10.1056/NEJMoa1205037?query=featured_home )Full Text (http://www.nejm.org/doi/full/10.1056/NEJMoa1205037?query=featured_home#t=article )Editorial (http://www.nejm.org/doi/full/10.1056/NEJMe1214816?query=featured_home )

Family Docs Are Early Adopters of Electronic Health Records

WEDNESDAY, Jan. 16 (HealthDay News) -- Family practice physicians are adopting electronic health record (EHR) systems at a fast pace, with 68 percent using an EHR system by 2011, and 80 percent expected to be users by 2013, according to research published in the January/February issue of the Annals of Family Medicine.

Abstract (http://annfammed.org/content/11/1/14.abstract )Full Text (http://annfammed.org/content/11/1/14.full )

Even Brief Interruptions Dramatically Increase Errors

WEDNESDAY, Jan. 16 (HealthDay News) -- Even momentary interruptions of two to four seconds can significantly affect a person's ability to accurately complete a task requiring considerable thought, according to research published online Jan. 7 in the Journal of Experimental Psychology: General.

Abstract (http://psycnet.apa.org/psycinfo/2013-00033-001/ )Full Text (subscription or payment may be required) (http://psycnet.apa.org/index.cfm?fa=buy.optionToBuy&id=2013-00033-001 )

Certain Online Behaviors of Docs Warrant Investigation

MONDAY, Jan. 14 (HealthDay News) -- There is high consensus among state medical boards regarding the likelihood of probable investigations for certain online behaviors, according to a study published in the Jan. 15 issue of the Annals of Internal Medicine.

Full Text (subscription or payment may be required) (http://annals.org/article.aspx?articleid=1556363 )

Top Five Issues for Docs and Patients Identified for 2013

MONDAY, Jan. 14 (HealthDay News) -- The top five issues that will impact physicians and patients in 2013 have been identified, according to a report published Dec. 10 by The Physicians Foundation.

More Information (http://www.physiciansfoundation.org/news/the-physicians-foundation-identifies-top-five-issues-to-impact-physicians-a/ )

New Hematuria Risk Index IDs Patients at Low Cancer Risk

MONDAY, Jan. 14 (HealthDay News) -- A Hematuria Risk Index could identify cancer risk among patients with asymptomatic microscopic hematuria, according to a study published online Jan. 11 in the Mayo Clinic Proceedings.

Abstract (http://www.mayoclinicproceedings.org/article/S0025-6196(12)00990-1/abstract )Full Text (http://www.mayoclinicproceedings.org/article/S0025-6196(12)00990-1/fulltext )

Smoking Plus Biomarker Panel IDs Bladder Cancer Prognosis

MONDAY, Jan. 14 (HealthDay News) -- Smoking intensity and a panel of nine cancer markers can be used to predict prognosis for patients with primary bladder tumors, according to research published online Jan. 14 in Cancer.

Abstract (http://onlinelibrary.wiley.com/doi/10.1002/cncr.27763/abstract )Full Text (subscription or payment may be required) (http://onlinelibrary.wiley.com/doi/10.1002/cncr.27763/full )

Lower Microbial Diversity for Infants Who Develop Colic

MONDAY, Jan. 14 (HealthDay News) -- In the first weeks of life, specific microbial signatures are present in infants who subsequently develop colic, according to research published online Jan. 14 in Pediatrics.

Abstract (http://pediatrics.aappublications.org/content/early/2013/01/08/peds.2012-1449.abstract )Full Text (subscription or payment may be required) (http://pediatrics.aappublications.org/content/early/2013/01/08/peds.2012-1449.full.pdf+html )

In Oropharyngeal Cancer, HPV Status Impacts Distant Mets Risk

MONDAY, Jan. 14 (HealthDay News) -- In patients with oropharyngeal cancer (OPC), human papillomavirus (HPV) status and T and N staging categories affect the rate of distant control (DC) and may help identify candidates for treatment deintensification strategies, according to research published online Jan. 7 in the Journal of Clinical Oncology.

Abstract (http://jco.ascopubs.org/content/early/2013/01/07/JCO.2012.44.0164.abstract )Full Text (subscription or payment may be required) (http://jco.ascopubs.org/content/early/2013/01/07/JCO.2012.44.0164.full.pdf+html )Editorial (http://jco.ascopubs.org/content/early/2013/01/07/JCO.2012.46.7746.full.pdf+html )

CDC: Flu Activity Remains High in the United States

FRIDAY, Jan. 11 (HealthDay News) -- Flu activity remains elevated, according to FluView, a weekly influenza surveillance report prepared by the Influenza Division of the U.S. Centers for Disease Control and Prevention; however, the annual flu vaccine is moderately effective at preventing the disease, according to a report published in the Jan. 11 early-release issue of CDC's Morbidity & Mortality Weekly Report.

FluView (http://www.cdc.gov/flu/weekly/ )Morbidity & Mortality Weekly Report (http://www.cdc.gov/mmwr/preview/mmwrhtml/mm62e0111a1.htm?s_cid=mm62e0111a1_w )

Psychiatric Risk Genes Linked to Brain Structure at Birth

FRIDAY, Jan. 11 (HealthDay News) -- Variants of several genes linked to psychiatric disorders are associated with changes in brain structure observable at birth, according to a study published online Jan. 2 in Cerebral Cortex.

Abstract (http://cercor.oxfordjournals.org/content/early/2013/01/02/cercor.bhs401.short?rss=1 )Full Text (subscription or payment may be required) (http://cercor.oxfordjournals.org/content/early/2013/01/02/cercor.bhs401.full )

Pap Smear DNA Shows Promise in ID'ing Endometrial, Ovarian CA

FRIDAY, Jan. 11 (HealthDay News) -- DNA from Papanicolaou (Pap) smears could potentially be used for detecting endometrial and ovarian cancer, according to a study published in the Jan. 9 issue of Science Translational Medicine.

Abstract (http://stm.sciencemag.org/content/5/167/167ra4 )Full Text (subscription or payment may be required) (http://stm.sciencemag.org/content/5/167/167ra4.full )Editorial (subscription or payment may be required) (http://stm.sciencemag.org/content/5/167/167ps1.abstract )

National U.S. Health Care Spending Relatively Stable

FRIDAY, Jan. 11 (HealthDay News) -- The growth in national U.S. health care spending was relatively stable in 2011, but growth in personal health care spending accelerated, according to a study published in the January issue of Health Affairs.

Abstract (http://content.healthaffairs.org/content/32/1/87.abstract )Full Text (subscription or payment may be required) (http://content.healthaffairs.org/content/32/1/87.full )

Etanercept Seems Beneficial in Partial Spinal Cord Injury

THURSDAY, Jan. 10 (HealthDay News) -- Treatment of rabbits with a partial spinal cord injury (SCI) with the intramuscularly-administered tumor necrosis factor-α (TNF-α) inhibitor etanercept is associated with improved clinical and electrophysiological recovery processes, according to research published in the December issue of the European Spine Journal.

Abstract (http://rd.springer.com/article/10.1007/s00586-012-2319-7# )Full Text (subscription or payment may be required) (http://rd.springer.com/article/10.1007/s00586-012-2319-7/fulltext.html )

Genetic CRC Risk Likely Mediated by Differential Adenoma Risk

THURSDAY, Jan. 10 (HealthDay News) -- Much of the genetic risk for colorectal cancer (CRC) in the general population is mediated by differential adenoma risk, according to research published in the January issue of Gastroenterology.

Abstract (http://www.gastrojournal.org/article/S0016-5085(12)01372-8/abstract )Full Text (subscription or payment may be required) (http://www.gastrojournal.org/article/S0016-5085(12)01372-8/abstract )

SPIRIT 2013 Clinical Trial Protocol Guidelines Issued

THURSDAY, Jan. 10 (HealthDay News) -- A panel of experts, including trial investigators, trial coordinators, and representatives from ethics and regulatory agencies, has developed the Standard Protocol Items: Recommendations for Interventional Trials (SPIRIT) 2013 guidelines for the minimum content of a clinical trial, according to a statement published online Jan. 8 in the Annals of Internal Medicine.

Abstract (http://annals.org/article.aspx?articleid=1556168#Abstract )Full Text (http://annals.org/article.aspx?articleid=1556168 )

Benefit of Sentinel Lymph Node Biopsy in Melanoma Unclear

WEDNESDAY, Jan. 9 (HealthDay News) -- Despite considerable controversy surrounding the third interim results of the Multicenter Selective Lymphadenectomy Trial (MSLT-I), which indicate a benefit of sentinel lymph node biopsy (SLNB) on disease-free survival in melanoma, the procedure is carried out routinely, according to a report published online Jan. 8 in BMJ.

Full Text (subscription or payment may be required) (http://www.bmj.com/content/346/bmj.e8645 )

Failure Rate of Cefixime for N. gonorrhoeae Infection Explored

TUESDAY, Jan. 8 (HealthDay News) -- For Neisseria gonorrhoeae (N. gonorrhoeae) infections, the rate of clinical treatment failure with cefixime is 6.77 percent, and is associated with minimum inhibitory concentrations (MICs) of 0.12 µg/mL or more, according to a study published in the Jan. 9 issue of the Journal of the American Medical Association.

Abstract (http://jama.jamanetwork.com/article.aspx?articleid=1556149#Abstract )Full Text (subscription or payment may be required) (http://jama.jamanetwork.com/article.aspx?articleid=1556149 )Editorial (subscription or payment may be required) (http://jama.jamanetwork.com/article.aspx?articleid=1556135 )

Fetuin-A Levels Linked to Cardiovascular Disease Risk

TUESDAY, Jan. 8 (HealthDay News) -- In elderly individuals without type 2 diabetes, high levels of fetuin-A, a protein that inhibits arterial calcification and insulin action, is associated with a lower risk of cardiovascular disease, according to a study published online Dec. 18 in Diabetes Care.

Abstract (http://care.diabetesjournals.org/content/early/2012/12/18/dc12-1591.abstract )Full Text (subscription or payment may be required) (http://care.diabetesjournals.org/content/early/2012/12/18/dc12-1591.full.pdf+html )

Ovarian Cancer Rates Declining in Breast Cancer Survivors

TUESDAY, Jan. 8 (HealthDay News) -- Primary ovarian cancer incidence is declining in the United States, both among the general population and among breast cancer survivors, according to research published online Jan. 2 in the Journal of Clinical Oncology.

Abstract (http://jco.ascopubs.org/content/early/2013/01/02/JCO.2012.43.2757.abstract )Full Text (subscription or payment may be required) (http://jco.ascopubs.org/content/early/2013/01/02/JCO.2012.43.2757.full.pdf+html )

Shared Savings May Promote Care Coordination Entity Use

MONDAY, Jan. 7 (HealthDay News) -- Use of shared savings could encourage individuals who are dually eligible for Medicare and Medicaid to enroll in state-designed care coordination entities (CCEs), according to a perspective piece published online Jan. 2 in the New England Journal of Medicine.

Full Text (http://www.nejm.org/doi/full/10.1056/NEJMp1214155 )

CDC: Influenza Activity Increasing Across the U.S.

FRIDAY, Jan. 4 (HealthDay News) -- Flu season descended on the United States early and hard this winter, with significant increases in flu activity observed over the past month, according to an update issued Jan. 4 by the U.S. Centers for Disease Control and Prevention.

More Information (http://www.cdc.gov/flu/spotlights/flu-activity-picks-up.htm )

FDA Proposes New Food Safety Standards

FRIDAY, Jan. 4 (HealthDay News) -- The U.S. Food and Drug Administration is proposing two new food safety rules as part of the implementation of the FDA Food Safety Modernization Act in an effort to shift the focus of food safety from reactive to preventive measures, according to a Jan. 4 news release issued by the agency.

More Information (http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm334156.htm )

Strong Genetic Selection Against Some Psych Disorders

FRIDAY, Jan. 4 (HealthDay News) -- Different evolutionary mechanisms likely support the persistence of various psychiatric disorders, according to a study published in the January issue of JAMA Psychiatry.

Abstract (http://archpsyc.jamanetwork.com/article.aspx?articleid=1390257#Abstract )Full Text (subscription or payment may be required) (http://archpsyc.jamanetwork.com/article.aspx?articleid=1390257 )

Pap Testing Moving Towards Alignment With Guidelines

FRIDAY, Jan. 4 (HealthDay News) -- Increasing numbers of women are receiving Papanicolau (Pap) screening for cervical cancer at an age and with a frequency consistent with the latest guidelines, according to two studies published in the Jan. 4 issue of the U.S. Centers for Disease Control and Prevention's Morbidity & Mortality Weekly Report.

Full Text - Saraiya (http://www.cdc.gov/mmwr/preview/mmwrhtml/mm6151a2.htm?s_cid=mm6151a2_w )Full Text - Watson (http://www.cdc.gov/mmwr/preview/mmwrhtml/mm6151a3.htm?s_cid=mm6151a3_w )

Tomosynthesis Ups Accuracy of Digital Mammography

FRIDAY, Jan. 4 (HealthDay News) -- Using a combination of tomosynthesis, which produces a three-dimensional reconstruction of the breast, with digital mammography increases radiologists' diagnostic accuracy and significantly lowers the number of recalls for non-cancer cases, according to research published in the January issue of Radiology.

Abstract (http://radiology.rsna.org/content/266/1/104.abstract )Full Text (subscription or payment may be required) (http://radiology.rsna.org/content/266/1/104.long )

Association Between Health Care Cost, Quality Inconsistent

THURSDAY, Jan. 3 (HealthDay News) -- The direction of the association between health care cost and quality is unclear, with inconsistent evidence indicating positive, negative, mixed, and indeterminate associations, according to a review published in the Jan. 1 issue of the Annals of Internal Medicine.

Full Text (subscription or payment may be required) (http://annals.org/article.aspx?articleid=1487781 )Editorial (subscription or payment may be required) (http://annals.org/article.aspx?articleid=1540566 )

Smoking Impairs Saphenous Vein Conduits in CABG Surgery

THURSDAY, Jan. 3 (HealthDay News) -- Patients undergoing heart bypass surgery using saphenous veins are more likely to have signs of graft failure if they are smokers, even if they quit smoking more than a year earlier, according to a study published in the January issue of the Annals of Thoracic Surgery.

Abstract (http://ats.ctsnetjournals.org/cgi/content/abstract/95/1/55 )Full Text (subscription or payment may be required) (http://ats.ctsnetjournals.org/cgi/content/full/95/1/55 )

House Joins Senate to Avert Medicare Cuts

WEDNESDAY, Jan. 2 (HealthDay News) -- The House of Representatives settled on an 11th-hour agreement late Tuesday night that has averted the widespread tax increases and spending cuts that would have gone into effect January 1. This agreement occurred 21 hours after the U.S. Senate did its part to steer the country clear of the "fiscal cliff."

More Information (http://www.whitehouse.gov/ )