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August 2013 Briefing - Pharmacy

August 2013 Briefing - Pharmacy

Here are what the editors at HealthDay consider to be the most important developments in Pharmacy for August 2013. This roundup includes the latest research news from journal articles, as well as the FDA approvals and regulatory changes that are the most likely to affect clinical practice.

Statins Appear to Benefit Elderly Without Previous CVD

FRIDAY, Aug. 30 (HealthDay News) -- Statins significantly reduce the incidence of myocardial infarction (MI) and stroke among elderly subjects without established cardiovascular (CV) disease, but do not significantly prolong survival in the short term, according to a review published online Aug. 28 in the Journal of the American College of Cardiology.

Full Text (subscription or payment may be required) (http://content.onlinejacc.org/article.aspx?articleid=1732396 )Editorial (subscription or payment may be required) (http://content.onlinejacc.org/article.aspx?articleid=1732395 )

FDA Investigating PML in Patient Taking MS Drug

FRIDAY, Aug. 30 (HealthDay News) -- The U.S. Food and Drug Administration is investigating the possible association between a rare brain infection and the multiple sclerosis (MS) drug Gilenya (fingolimod), according to a drug safety alert issued by the agency.

More Information (http://www.fda.gov/Safety/MedWatch/SafetyInformation/SafetyAlertsforHumanMedicalProducts/ucm366751.htm )

Comprehensive Stroke System Key to Reducing Death

FRIDAY, Aug. 30 (HealthDay News) -- A comprehensive stroke care system that addresses patient needs from symptom onset through rehabilitation can reduce stroke-related death and disability, according to an American Heart Association/American Stroke Association policy statement published online Aug. 29 in Stroke.

Full Text (http://stroke.ahajournals.org/content/early/2013/08/29/STR.0b013e3182a6d2b2.full.pdf+html )

Unintentional Buprenorphine Exposure Dangerous for Kids

FRIDAY, Aug. 30 (HealthDay News) -- Unintentional exposure to buprenorphine (intended to treat adults with opioid addiction) can cause serious adverse events, including death, in young children, according to a study published online Aug. 29 in The Journal of Pediatrics.

Full Text (http://www.jpeds.com/webfiles/images/journals/ympd/JPEDSLavonas.pdf )

Discontinuing Aspirin Seven Days Before Spinal Surgery OK

FRIDAY, Aug. 30 (HealthDay News) -- Patients who discontinue aspirin use seven days or more before lumbar fusion surgery have no differences in histological outcomes compared with those who do not use aspirin, according to a study published in the Aug. 15 issue of Spine.

Abstract (http://journals.lww.com/spinejournal/Abstract/2013/08150/Antithrombotic_Effects_of_Aspirin_on_1__or_2_Level.6.aspx )Full Text (subscription or payment may be required) (http://journals.lww.com/spinejournal/Abstract/2013/08150/Antithrombotic_Effects_of_Aspirin_on_1__or_2_Level.6.aspx )

Death Risk Higher With Mental Illness in Drug Trials

THURSDAY, Aug. 29 (HealthDay News) -- Adults with psychiatric illnesses such as schizophrenia, depression, and bipolar disorder who participate in clinical trials of psychopharmacological drugs have a higher mortality risk, in many cases by suicide, according to a study published online Aug. 28 in JAMA Psychiatry.

Abstract (http://archpsyc.jamanetwork.com/article.aspx?articleid=1733743#Abstract )Full Text (subscription or payment may be required) (http://archpsyc.jamanetwork.com/article.aspx?articleid=1733743 )

CDC: Most Teen Immunizations on the Rise

THURSDAY, Aug. 29 (HealthDay News) -- Vaccination coverage in youths for tetanus, diphtheria, and acellular pertussis (Tdap) and meningococcal conjugate (MenACWY) has been increasing since 2009, but there is still a ways to go before achieving the Healthy People 2020 targets for adolescents, according to a report published in the Aug. 30 issue of the U.S. Centers for Disease Control and Prevention's Morbidity and Mortality Weekly Report.

Full Text (http://www.cdc.gov/mmwr/preview/mmwrhtml/mm6234a1.htm?s_cid=mm6234a1_w )

Prevalence of Rx Sleeping Aid Use 4 Percent for U.S. Adults

THURSDAY, Aug. 29 (HealthDay News) -- The prevalence of prescription sleep aid use in the past month is about 4 percent among U.S. adults aged 20 years and older, according to a report published Aug. 29 by the National Center for Health Statistics (NCHS).

More Information (http://www.cdc.gov/nchs/data/databriefs/db127.htm )

Final Rules Issued for Individual Shared Responsibility Mandate

WEDNESDAY, Aug. 28 (HealthDay News) -- Starting 2014, the individual shared responsibility provision of the Affordable Care Act, which calls for each individual to have basic health insurance coverage, will be implemented, according to a statement from the U.S. Department of the Treasury.

More Information (http://www.treasury.gov/press-center/press-releases/Pages/jl2152.aspx )

Macitentan Cuts Morbidity, Death in Pulmonary Arterial HTN

WEDNESDAY, Aug. 28 (HealthDay News) -- For patients with pulmonary arterial hypertension, the new dual endothelin-receptor antagonist macitentan is associated with reductions in morbidity and mortality, according to a study published in the Aug. 29 issue of the New England Journal of Medicine.

Full Text (subscription or payment may be required) (http://www.nejm.org/doi/full/10.1056/NEJMoa1213917?query=featured_home )

Oral Fluconazole in Pregnancy Not Linked to Most Birth Defects

WEDNESDAY, Aug. 28 (HealthDay News) -- Commonly used low doses of fluconazole during pregnancy do not increase the risk of most birth defects but may confer an increased risk of tetralogy of Fallot, according to a study published in the Aug. 29 issue of the New England Journal of Medicine.

Full Text (subscription or payment may be required) (http://www.nejm.org/doi/full/10.1056/NEJMoa1301066 )

Severe Gastroenteritis Down in Older Children and Adults

WEDNESDAY, Aug. 28 (HealthDay News) -- Reduced hospitalizations for gastroenteritis among children aged 5 years or older and among adults in post-vaccine years in the United States suggest indirect protection from infant rotavirus vaccination, according to research published in the Aug. 28 issue of the Journal of the American Medical Association.

Full Text (subscription of payment may be required) (http://jama.jamanetwork.com/article.aspx?articleid=1733704 )

Health Care Savings With Early Accountable Care Organizations

WEDNESDAY, Aug. 28 (HealthDay News) -- Early accountable care organization initiatives correlate with lower spending for elderly Medicare beneficiaries, but not necessarily with improved quality, according to a study published in the Aug. 28 issue of the Journal of the American Medical Association.

Abstract (http://jama.jamanetwork.com/article.aspx?articleid=1733718#Abstract )Full Text (subscription of payment may be required) (http://jama.jamanetwork.com/article.aspx?articleid=1733718 )

Use of Antipsychotic Meds Down in Nursing Homes

WEDNESDAY, Aug. 28 (HealthDay News) -- There has been a decrease in the national prevalence of antipsychotic medication use among nursing home residents, according to a report published by the Centers for Medicare & Medicaid Services (CMS).

More Information (http://www.cms.gov/Newsroom/MediaReleaseDatabase/Press-Releases/2013-Press-Releases-Items/2013-08-27.html )

Sofosbuvir + Ribavirin Effective for Difficult Hepatitis C Cases

TUESDAY, Aug. 27 (HealthDay News) -- In patients with chronic hepatitis C virus (HCV) with unfavorable treatment characteristics, treatment with sofosbuvir and ribavirin reduces viral load to undetectable levels in many patients, according to a study published in the Aug. 28 issue of the Journal of the American Medical Association.

Abstract (http://jama.jamanetwork.com/article.aspx?articleid=1733720#Abstract )Full Text (subscription or payment may be required) (http://jama.jamanetwork.com/article.aspx?articleid=1733720 )

More Pediatric HIV Patients on Antiretroviral Therapy

TUESDAY, Aug. 27 (HealthDay News) -- The proportion of perinatally HIV (PHIV)-infected youth on antiretroviral therapy (ART) has increased, leading to decreases in rates of viremia and advanced immunosuppression in recent years, according to a study published in the September issue of the Journal of the Pediatric Infectious Diseases Society.

Abstract (http://jpids.oxfordjournals.org/content/early/2013/03/12/jpids.pit008.abstract?sid=e9218229-8a8a-4031-90be-c796fdd2c810 )Full Text (subscription or payment may be required) (http://jpids.oxfordjournals.org/content/early/2013/03/12/jpids.pit008.full )

Specific Lymphoma Treatment Linked to Stomach Cancer

MONDAY, Aug. 26 (HealthDay News) -- Patients with Hodgkin's lymphoma treated with high-dose radiation to the stomach and high-dose chemotherapy with procarbazine have a nearly 80-fold higher risk of developing stomach cancer, according to a study published online Aug. 26 in the Journal of Clinical Oncology.

Abstract (http://jco.ascopubs.org/content/early/2013/08/22/JCO.2013.50.6832.abstract )Full Text (subscription or payment may be required) (http://jco.ascopubs.org/content/early/2013/08/22/JCO.2013.50.6832.full.pdf+html )

Heroin Incidence Up for Those Using Non-Medical Pain Relief

MONDAY, Aug. 26 (HealthDay News) -- The rate of heroin initiation is much higher among those who have previously used non-medical pain relievers (NMPR), although only a small percentage of those using NMPRs actually progress to heroin use, according to a report published by the Substance Abuse and Mental Health Services Administration (SAMHSA).

More Information (http://www.samhsa.gov/data/2k13/DataReview/DR006/nonmedical-pain-reliever-use-2013.pdf )

CDC Ups Miltefosine Access for Free-Living Amebae Infections

MONDAY, Aug. 26 (HealthDay News) -- For patients with infections caused by free-living amebae (FLA), including primary amebic meningoencephalitis caused by Naegleria fowleri and granulomatous amebic encephalitis caused by Balamuthia mandrillaris and Acanthamoeba species, the investigational drug miltefosine is now available for treatment from the U.S. Centers for Disease Control and Prevention, according to a report published in the Aug. 23 issue of the CDC's Morbidity and Mortality Weekly Report.

Full Text (http://www.cdc.gov/mmwr/preview/mmwrhtml/mm6233a4.htm?s_cid=mm6233a4_x )

Correct Dose of Anti-Clotting Rx in Elderly Continues to Elude

MONDAY, Aug. 26 (HealthDay News) -- There are no differences in ischemic or bleeding outcomes with reduced-dose prasugrel versus clopidogrel in elderly patients with acute coronary syndromes (ACS), according to a study published in the Aug. 20 issue of Circulation.

Abstract (http://circ.ahajournals.org/content/128/8/823.abstract )Full Text (subscription or payment may be required) (http://circ.ahajournals.org/content/128/8/823.full )

Calcium + Vitamin D Does Not Reduce Joint Symptoms

MONDAY, Aug. 26 (HealthDay News) -- Calcium plus vitamin D supplementation does not reduce the frequency or severity of joint symptoms in women, according to a study published online Aug. 19 in the Journal of the Academy of Nutrition and Dietetics.

Abstract (http://www.andjrnl.org/article/S2212-2672%2813%2900685-0/abstract )Full Text (subscription or payment may be required) (http://www.andjrnl.org/article/S2212-2672%2813%2900685-0/fulltext )

Most Drugs Safe to Take While Breastfeeding

MONDAY, Aug. 26 (HealthDay News) -- Most medications are safe to take while breastfeeding, according to updated guidelines from the American Academy of Pediatrics (AAP) published online Aug. 26 in Pediatrics.

LactMed (http://toxnet.nlm.nih.gov/cgi-bin/sis/htmlgen?LACT )Abstract (http://pediatrics.aappublications.org/content/early/2013/08/20/peds.2013-1985.abstract )Full Text (http://pediatrics.aappublications.org/content/early/2013/08/20/peds.2013-1985.full.pdf+html )

tPA Use in Ischemic Stroke Nearly Doubled 2003 to 2011

FRIDAY, Aug. 23 (HealthDay News) -- The use of intravenous tissue plasminogen activator (IV tPA) in acute ischemic stroke (AIS) patients nearly doubled from 2003 to 2011, according to research published online Aug. 20 in Circulation: Cardiovascular Quality and Outcomes.

Abstract (http://circoutcomes.ahajournals.org/content/early/2013/08/20/CIRCOUTCOMES.111.000095.abstract )Full Text (subscription or payment may be required) (http://circoutcomes.ahajournals.org/content/early/2013/08/20/CIRCOUTCOMES.111.000095.full.pdf+html )

Ultra-Early IV Thrombolysis Minimizes Stroke Disability

THURSDAY, Aug. 22 (HealthDay News) -- Ultra-early intravenous thrombolysis increases the likelihood of an excellent outcome in patients with moderate and mild stroke symptoms, according to research published online Aug. 22 in Stroke.

Abstract (http://stroke.ahajournals.org/content/early/2013/08/22/STROKEAHA.111.000819.abstract )Full Text (http://stroke.ahajournals.org/content/early/2013/08/22/STROKEAHA.111.000819.full.pdf+html )

Early Time-Limited Bests Deferred ART in Infants With HIV

THURSDAY, Aug. 22 (HealthDay News) -- For HIV-infected asymptomatic infants, early time-limited antiretroviral therapy (ART) is associated with better clinical and immunological outcomes, compared with deferred ART, according to a study published online Aug. 22 in The Lancet.

Abstract (http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(13)61409-9/abstract )Full Text (subscription or payment may be required) (http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(13)61409-9/fulltext )Editorial (subscription or payment may be required) (http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(13)61717-1/fulltext )

Antipsychotic Use Among Youth Ups Type 2 Diabetes Risk

THURSDAY, Aug. 22 (HealthDay News) -- Among youth aged 6 to 24 years, recent initiation of antipsychotics is associated with a significantly increased risk of type 2 diabetes, according to a study published online Aug. 21 in JAMA Psychiatry.

Abstract (http://archpsyc.jamanetwork.com/article.aspx?articleid=1731662#Abstract )Full Text (subscription or payment may be required) (http://archpsyc.jamanetwork.com/article.aspx?articleid=1731662 )

Tofacitinib Ups Rheumatoid Arthritis Treatment Response

THURSDAY, Aug. 22 (HealthDay News) -- The addition of tofacitinib to rheumatoid arthritis (RA) treatment regimens improves patient response to non-biologic disease-modifying antirheumatic drugs (DMARDs), according to a study published in the Aug. 20 issue of the Annals of Internal Medicine.

Full Text (subscription or payment may be required) (http://annals.org/article.aspx?articleid=1726820 )

Dipyrone Negates Aspirin's Antiplatelet Effect

THURSDAY, Aug. 22 (HealthDay News) -- There is an unfavorable pharmacological drug interaction between the non-narcotic analgesic dipyrone and aspirin in patients with coronary artery disease (CAD), according to research published online Aug. 14 in the Journal of the American College of Cardiology.

Full Text (subscription or payment may be required) (http://content.onlinejacc.org/article.aspx?articleid=1729175 )

Drugs Show Similar Efficacy in Metastatic Kidney Cancer

WEDNESDAY, Aug. 21 (HealthDay News) -- While pazopanib and sunitinib are similarly effective in patients with metastatic renal-cell cancer, pazopanib is associated with better safety and quality of life, according to a study published in the Aug. 22 issue of the New England Journal of Medicine.

Full Text (subscription or payment may be required) (http://www.nejm.org/doi/full/10.1056/NEJMoa1303989 )

Vedolizumab Ups Response Rate in Ulcerative Colitis

WEDNESDAY, Aug. 21 (HealthDay News) -- Vedolizumab is associated with improved clinical response and remission versus placebo for patients with ulcerative colitis or Crohn's disease, according to two studies published in the Aug. 22 issue of the New England Journal of Medicine.

Full Text - Feagan (subscription or payment may be required) (http://www.nejm.org/doi/full/10.1056/NEJMoa1215734?query=featured_home )Full Text - Sandborn (subscription or payment may be required) (http://www.nejm.org/doi/full/10.1056/NEJMoa1215739?query=featured_home )Editorial (subscription or payment may be required) (http://www.nejm.org/doi/full/10.1056/NEJMe1307415?query=featured_home )

Use of TNF Inhibitors in Crohn's Disease Discussed

WEDNESDAY, Aug. 21 (HealthDay News) -- For patients with Crohn's disease with active inflammation despite receiving standard treatment, tumor necrosis factor (TNF) inhibitors are recommended, according to a case vignette published in the Aug. 22 issue of the New England Journal of Medicine.

Full Text (subscription or payment may be required) (http://www.nejm.org/doi/full/10.1056/NEJMct1209614 )

Hispanic Teens More Likely to Engage in Substance Abuse

WEDNESDAY, Aug. 21 (HealthDay News) -- Hispanic teenagers are more likely to engage in substance abuse than Caucasian or African-American teenagers, and are more likely to be offered drugs in their lifetime and at school, according to a report sponsored by MetLife Foundation and published by The Partnership at Drugfree.org.

More Information (http://www.drugfree.org/newsroom/hispanic-teen-drug-use-pats )

Haloperidol Has No Effect on Delirium in Critically Ill Patients

WEDNESDAY, Aug. 21 (HealthDay News) -- In critically ill patients requiring ventilation, haloperidol treatment does not affect the amount of time alive without delirium or coma compared with placebo, according to a study published online Aug. 21 in The Lancet Respiratory Medicine.

Abstract (http://www.thelancet.com/journals/lanres/article/PIIS2213-2600(13)70166-8/abstract )Full Text (subscription or payment may be required) (http://www.thelancet.com/journals/lanres/article/PIIS2213-2600(13)70166-8/fulltext )Editorial (subscription or payment may be required) (http://www.thelancet.com/journals/lanres/article/PIIS2213-2600(13)70178-4/fulltext )

Implications, Solutions for U.S. Health Disparities Discussed

TUESDAY, Aug. 20 (HealthDay News) -- Research on health disparities in the United States, the policy implications of these disparities, and suggestions for improvement of disparities are discussed in "Health Policy Brief: Health Gaps," published Aug. 15 in Health Affairs.

Full Text (http://www.healthaffairs.org/healthpolicybriefs/brief.php?brief_id=98 )

Oral Fluoroquinolones Linked to Dysglycemia Risk in Diabetes

TUESDAY, Aug. 20 (HealthDay News) -- Patients with diabetes using oral fluoroquinolones face an increased risk of severe dysglycemia, according to a study published online Aug. 14 in Clinical Infectious Diseases.

Abstract (http://cid.oxfordjournals.org/content/early/2013/07/23/cid.cit439.abstract )Full Text (subscription or payment may be required) (http://cid.oxfordjournals.org/content/early/2013/07/23/cid.cit439.full )

Lasting Benefits With Insulin Pump Therapy for Children

TUESDAY, Aug. 20 (HealthDay News) -- Insulin pump therapy is associated with sustained improvement in glycemic control as well as reductions in severe hypoglycemia and hospitalization for diabetic ketoacidosis (DKA) in children with type 1 diabetes, according to a study published online Aug. 18 in Diabetologia.

Full Text (http://www.diabetologia-journal.org/files/Johnson.pdf )

Expansion of Pharmacists' Practice Will Benefit Patients

MONDAY, Aug. 19 (HealthDay News) -- The expanding scope of pharmacists' practice will potentially improve patient care but has implications for physicians, according to an article published online Aug. 19 in CMAJ, the journal of the Canadian Medical Association.

Full Text (subscription or payment may be required) (http://www.cmaj.ca/content/early/2013/08/19/cmaj.121990 )

Onset of Puberty Is Delayed in HIV-Infected Children

MONDAY, Aug. 19 (HealthDay News) -- Onset of puberty is significantly delayed in perinatally HIV-infected (PHIV) children compared with those who are HIV-exposed but uninfected (HEU), but combination antiretroviral therapy may result in more normal timing of pubertal onset, according to research published in the July 31 issue of AIDS.

Abstract (http://journals.lww.com/aidsonline/Abstract/2013/07310/Pubertal_onset_in_children_with_perinatal_HIV.13.aspx )Full Text (subscription or payment may be required) (http://journals.lww.com/aidsonline/Abstract/2013/07310/Pubertal_onset_in_children_with_perinatal_HIV.13.aspx )

Low-Dose Desmopressin Effective for Nocturia

MONDAY, Aug. 19 (HealthDay News) -- Desmopressin orally disintegrating tablets are effective and well-tolerated for nocturia among women and men at doses of 25 and 50 µg per day, respectively, according to two studies published in the September issue of The Journal of Urology.

Abstract - Sand (http://www.jurology.com/article/S0022-5347(13)00310-8/abstract )Full Text (http://www.jurology.com/article/S0022-5347(13)00310-8/fulltext )Abstract - Weiss (http://www.jurology.com/article/S0022-5347(13)00313-3/abstract )Full Text (http://www.jurology.com/article/S0022-5347(13)00313-3/fulltext )Editorial (subscription or payment may be required) (http://www.jurology.com/article/S0022-5347(13)04628-4/fulltext )

HHS Awards $67 Million to Marketplace Navigators

MONDAY, Aug. 19 (HealthDay News) -- $67 million is being awarded to Navigator grant applicants and their staff, who will serve as an in-person resource for those requiring additional assistance in shopping for and enrolling in Health Insurance Marketplace plans, according to a report published by the U.S. Department of Health and Human Services.

More Information (http://www.hhs.gov/news/press/2013pres/08/20130815a.html )

Some Neurologists Unaware of Epileptic Drug Risks

MONDAY, Aug. 19 (HealthDay News) -- About one in five neurologists in the United States are not aware of recent warnings from the U.S. Food and Drug Administration regarding anti-epileptic drugs, according to a study published in the October issue of Epilepsy & Behavior.

Full Text (http://www.sciencedirect.com/science/article/pii/S1525505013002862 )

FDA: Fluoroquinolones May Cause Irreversible Nerve Damage

FRIDAY, Aug. 16 (HealthDay News) -- Fluoroquinolone antibacterial drugs may cause permanent nerve damage; the U.S. Food and Drug Administration is requiring updated drug labels and medication guides to reflect this fact, according to a Drug Safety Communication issued by the agency.

More Information (http://www.fda.gov/Safety/MedWatch/SafetyInformation/SafetyAlertsforHumanMedicalProducts/ucm365302.htm?source=govdelivery )

Metformin Usually Adequate for Control of Gestational Diabetes

FRIDAY, Aug. 16 (HealthDay News) -- Among women with gestational diabetes mellitus, those receiving metformin achieve lower mean glucose levels compared with those receiving insulin, but some require supplemental insulin therapy, according to research published in the July issue of the American Journal of Obstetrics & Gynecology.

Abstract (http://www.ajog.org/article/S0002-9378(13)00296-2/abstract )Full Text (subscription or payment may be required) (http://www.ajog.org/article/S0002-9378(13)00296-2/fulltext )

Few Urologists Follow Peri-Op Thromboprophylaxis Guidelines

FRIDAY, Aug. 16 (HealthDay News) -- Among American Urological Association (AUA) members, self-reported adherence to the Best Practice Statement on the use of thromboprophylaxis in patients undergoing urological procedures is low, according to research published in the September issue of The Journal of Urology.

Abstract (http://www.jurology.com/article/S0022-5347(13)03868-8/abstract )Full Text (subscription or payment may be required) (http://www.jurology.com/article/S0022-5347(13)03868-8/fulltext )

IOM Describes Themes Relating to Patients' Role in Health Care

FRIDAY, Aug. 16 (HealthDay News) -- Themes and messages relating to the role of patients in informed care decisions, knowledge generation, and value improvement were discussed at the Institute of Medicine's (IOM) Workshop Proceedings, according to a report published Aug. 15 in conjunction with the transcript of the proceedings.

More Information (http://www.iom.edu/Reports/2013/Partnering-with-Patients-to-Drive-Shared-Decisions-Better-Value-and-Care-Improvement.aspx )

Childhood ADHD Linked to Atopic Diseases, Impetigo

FRIDAY, Aug. 16 (HealthDay News) -- For boys with attention-deficit/hyperactivity disorder (ADHD), the likelihoods of asthma, impetigo, and any antihistamine drug prescriptions are independently increased, according to a study published in the August issue of the Annals of Allergy, Asthma & Immunology.

Abstract (http://www.annallergy.org/article/S1081-1206(13)00357-8/abstract )Full Text (subscription or payment may be required) (http://www.annallergy.org/article/S1081-1206(13)00357-8/fulltext )

Involved Patients Have Better Health Care Experiences

THURSDAY, Aug. 15 (HealthDay News) -- Health care providers and patients shape the care experience, and strategies to improve care interactions should also help patients ensure that their needs are met, according to research published in the July issue of Health Affairs.

Abstract (http://content.healthaffairs.org/content/32/7/1299.abstract )Full Text (subscription or payment may be required) (http://content.healthaffairs.org/content/32/7/1299.full )

Liraglutide Augments Weight Loss in Pre-Type 2 Diabetes

THURSDAY, Aug. 15 (HealthDay News) -- For patients at high risk of type 2 diabetes mellitus (T2DM) and cardiovascular disease (CVD), liraglutide in additional to calorie restriction is associated with more weight loss and improvements in insulin resistance, glucose tolerance, and some CVD risk factors, according to a study published online July 8 in Diabetes Care.

Abstract (http://care.diabetesjournals.org/content/early/2013/05/14/dc13-0354.abstract )Full Text (subscription or payment may be required) (http://care.diabetesjournals.org/content/early/2013/05/14/dc13-0354.full.pdf+html )

Interferon-Free Treatment Effective in Hepatitis C Virus

WEDNESDAY, Aug. 14 (HealthDay News) -- For patients with hepatitis C virus (HCV), treatment with faldaprevir and deleobuvir plus ribavirin is effective, according to a study published in the Aug. 15 issue of the New England Journal of Medicine.

Full Text (subscription or payment may be required) (http://www.nejm.org/doi/full/10.1056/NEJMoa1213557 )

Long-Term Survival No Better With Finasteride in Prostate CA

WEDNESDAY, Aug. 14 (HealthDay News) -- Finasteride is associated with a reduction in the risk of prostate cancer, but is not associated with improved survival over 18 years, according to a study published in the Aug. 15 issue of the New England Journal of Medicine.

Full Text (subscription or payment may be required) (http://www.nejm.org/doi/full/10.1056/NEJMoa1215932?query=featured_home )Editorial (subscription or payment may be required) (http://www.nejm.org/doi/full/10.1056/NEJMe1307059?query=featured_home )

Vitamin D Doesn't Improve Blood Pressure in Elderly

WEDNESDAY, Aug. 14 (HealthDay News) -- Vitamin D supplementation does not improve blood pressure (BP) in older patients with isolated systolic hypertension, according to a study published online Aug. 12 in JAMA Internal Medicine.

Abstract (http://archinte.jamanetwork.com/article.aspx?articleid=1726994#Abstract )Full Text (subscription or payment may be required) (http://archinte.jamanetwork.com/article.aspx?articleid=1726994 )

FDA Approves New Drug to Treat HIV-1

TUESDAY, Aug. 13 (HealthDay News) -- Tivicay (dolutegravir) has been approved by the U.S. Food and Drug Administration to treat infection with HIV-1, a strain of the virus that causes AIDS.

More Information (http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm364744.htm )

New Initiative Announced for Patient-Doc Collaboration

TUESDAY, Aug. 13 (HealthDay News) -- A new Center for Patient Partnership in Healthcare (CPPH) has been launched to advance physician-patient collaboration, according to a report published by the American College of Physicians (ACP).

More Information (http://www.acponline.org/pressroom/cpph.htm?hp )

U.S. Hospitals Up Exchange of Electronic Health Information

MONDAY, Aug. 12 (HealthDay News) -- Between 2008 and 2012, hospitals significantly increased their exchange of electronic health information with other providers, according to research published in the August issue of Health Affairs.

Abstract (http://content.healthaffairs.org/content/32/8/1346.abstract )Full Text (subscription or payment may be required) (http://content.healthaffairs.org/content/32/8/1346.full )

ER Visits Related to Use of CNS Stimulants Up From '05 to '11

MONDAY, Aug. 12 (HealthDay News) -- From 2005 to 2011, the number of emergency department visits related to nonmedical use of central nervous system (CNS) stimulants increased about four-fold among 18- to 34-year-olds, according to a report published Aug. 8 by the U.S. Substance Abuse and Mental Health Services Administration (SAMHSA).

More Information (http://www.samhsa.gov/data/spotlight/spot103-CNS-stimulants-adults.pdf )

Guidelines for Post-HIV Exposure Management Updated

MONDAY, Aug. 12 (HealthDay News) -- Management and prophylaxis recommendations have been updated for health care providers with occupational exposure to HIV, according to guidelines published in the September issue of Infection Control and Hospital Epidemiology.

Full Text (http://www.jstor.org/stable/10.1086/672271 )

Wide Treatment Variances Seen With ADHD Drugs

FRIDAY, Aug. 9 (HealthDay News) -- There are wide variations in the use of stimulants to treat attention-deficit/hyperactivity disorder at both the state and the county level, according to research published online Aug. 2 in Psychiatric Services.

Abstract (http://ps.psychiatryonline.org/article.aspx?articleID=1724475 )Full Text (subscription or payment may be required) (http://ps.psychiatryonline.org/article.aspx?articleID=1724475 )

Gene Variants Linked to Obesity

THURSDAY, Aug. 8 (HealthDay News) -- Variants of a gene are associated with overweight and obesity in psychiatric patients taking drugs that induce weight gain, as well in the general population, according to a study published online Aug. 7 in JAMA Psychiatry.

Abstract (http://archpsyc.jamanetwork.com/article.aspx?articleid=1725658#Abstract )Full Text (subscription or payment may be required) (http://archpsyc.jamanetwork.com/article.aspx?articleid=1725658 )

Probiotic Preparation Doesn't Cut Antibiotic-Linked Diarrhea

THURSDAY, Aug. 8 (HealthDay News) -- A multi-strain preparation of lactobacilli and bifidobacteria is not effective for preventing antibiotic-associated diarrhea (AAD) or Clostridium difficile diarrhea (CDD) in older inpatients exposed to antibiotics, according to a study published online Aug. 8 in The Lancet.

Abstract (http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(13)61218-0/abstract )Full Text (subscription or payment may be required) (http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(13)61218-0/fulltext )Editorial (subscription or payment may be required) (http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(13)61571-8/fulltext )

Self-Measured Monitoring Improves Blood Pressure

WEDNESDAY, Aug. 7 (HealthDay News) -- Self-measured blood pressure (SMBP) monitoring lowers BP in the short-term, according to a review published in the Aug. 6 issue of the Annals of Internal Medicine.

Full Text (subscription or payment may be required) (http://annals.org/article.aspx?articleid=1722499 )

Review Looks at Antibiotic Rx in Ambulatory Settings

WEDNESDAY, Aug. 7 (HealthDay News) -- Most ambulatory care antibiotic prescriptions are for broad-spectrum agents, which are commonly prescribed for conditions for which antibiotics are rarely indicated, according to research published online July 25 in the Journal of Antimicrobial Chemotherapy.

Abstract (http://jac.oxfordjournals.org/content/early/2013/07/24/jac.dkt301.abstract )Full Text (subscription or payment may be required) (http://jac.oxfordjournals.org/content/early/2013/07/24/jac.dkt301.full )

AMA, AHA Call for Realignment of Meaningful Use Stage 2

WEDNESDAY, Aug. 7 (HealthDay News) -- The American Medical Association (AMA) and American Hospital Association (AHA) are calling for additional flexibility in the timing of the adoption of stage 2 meaningful use of electronic health records, according to a letter written to the U.S. Department of Health and Human Services (HHS).

More Information (http://www.amednews.com/article/20130805/government/130809987/1/ )

Cumulative Metformin Linked to Mortality Post-Prostate Cancer

WEDNESDAY, Aug. 7 (HealthDay News) -- Among elderly men with diabetes, increased cumulative duration of metformin following a prostate cancer (PC) diagnosis correlates with decreased all-cause and PC-specific mortality, according to a study published online Aug. 5 in the Journal of Clinical Oncology.

Abstract (http://jco.ascopubs.org/content/early/2013/08/05/JCO.2012.46.7043.abstract )Full Text (subscription or payment may be required) (http://jco.ascopubs.org/content/early/2013/08/05/JCO.2012.46.7043.full.pdf+html )Editorial (http://jco.ascopubs.org/content/early/2013/08/05/JCO.2013.50.7715 )

Drug-Resistant Bacteria Spread Regionally Through Hospitals

TUESDAY, Aug. 6 (HealthDay News) -- An increase in vancomycin-resistant enterococci (VRE) colonization prevalence correlates with increased prevalence in other hospitals, with larger hospitals having greater effects on other hospitals, according to a study published in the August issue of the American Journal of Infection Control.

Abstract (http://www.ajicjournal.org/article/S0196-6553(13)00113-2/abstract )Full Text (http://www.ajicjournal.org/article/S0196-6553(13)00113-2/fulltext )

No Increased Cancer Risk With Glargine Versus Human Insulin

TUESDAY, Aug. 6 (HealthDay News) -- There is no evidence that patients with diabetes who initiate insulin glargine have a higher risk of cancer than similar patients initiating human neutral protamine Hagedorn (NPH) insulin, according to a study published online July 22 in Diabetes Care.

Abstract (http://care.diabetesjournals.org/content/early/2013/07/18/dc13-0263.abstract )Full Text (subscription or payment may be required) (http://care.diabetesjournals.org/content/early/2013/07/18/dc13-0263.full.pdf+html )

Cellular + Gene Rx Promising for Breast Cancer Metastatic to Brain

TUESDAY, Aug. 6 (HealthDay News) -- Cellular immunotherapy and gene therapy alone or in combination are effective in reducing tumor size and improving survival in a mouse model of breast cancers that have metastasized to the brain, according to a study published in the Aug. 1 issue of Clinical Cancer Research.

Abstract (http://clincancerres.aacrjournals.org/content/19/15/4137.abstract )Full Text (subscription or payment may be required) (http://clincancerres.aacrjournals.org/content/19/15/4137.full )

FDA Approves Shipping of Fluarix Quadrivalent Vaccine

TUESDAY, Aug. 6 (HealthDay News) -- The U.S. Food and Drug Administration has approved shipping of the GlaxoSmithKline (GSK) 2013 to 2014 Fluarix Quadrivalent influenza virus vaccine to U.S. Centers for Disease Control and Prevention's distribution centers and U.S. health care providers.

More Information (http://us.gsk.com/html/media-news/pressreleases/2013/glaxomithkline-receives-fda-approval-to-ship-four-strain-quadrivalent-influenza-vaccine-to-healthcare-providers.html )

Long-Term Calcium-Channel Blockers Tied to Breast CA Risk

MONDAY, Aug. 5 (HealthDay News) -- For postmenopausal women, long-term use of calcium-channel blockers may be associated with an increased risk of invasive ductal and lobular breast cancer, according to a study published online Aug. 5 in JAMA Internal Medicine.

Abstract (http://archinte.jamanetwork.com/article.aspx?articleid=1723871#Abstract )Full Text (subscription or payment may be required) (http://archinte.jamanetwork.com/article.aspx?articleid=1723871 )Editorial (subscription or payment may be required) (http://archinte.jamanetwork.com/article.aspx?articleid=1723870 )

Participation Increases in Online CME Activities

MONDAY, Aug. 5 (HealthDay News) -- The number of physicians and non-physicians participating in continuing medical education (CME) has increased, especially in online activities, according to a report published by the Accreditation Council for Continuing Medical Education (ACCME).

More Information (http://accme.org/sites/default/files/630_2012_Annual_Report_20130724_0.pdf )

Antioxidants Don't Up Fertility Outcomes for Subfertile Women

MONDAY, Aug. 5 (HealthDay News) -- Antioxidant supplementation does not effectively increase rates of live birth or clinical pregnancy in subfertile women, according to a review published online Aug. 5 in The Cochrane Library.

Abstract (http://onlinelibrary.wiley.com/doi/10.1002/14651858.CD007807.pub2/abstract )Full Text (subscription or payment may be required) (http://onlinelibrary.wiley.com/doi/10.1002/14651858.CD007807.pub2/full )

MMR, DTaP, Varicella Vaccine Coverage Close to 95 Percent

MONDAY, Aug. 5 (HealthDay News) -- The vaccination coverage rates for measles, mumps, and rubella (MMR); diphtheria, tetanus toxoid, and acellular pertussis (DTaP); and varicella vaccine are close to 95 percent among children entering kindergarten for the year 2012 to 2013, according to a report published in the Aug. 2 issue of the U.S. Centers for Disease Control and Prevention's Morbidity and Mortality Weekly Report.

Full Text (http://www.cdc.gov/mmwr/preview/mmwrhtml/mm6230a3.htm )

Asthma During Pregnancy Linked to Disease in Offspring

MONDAY, Aug. 5 (HealthDay News) -- Asthma during pregnancy is associated with an increased risk of diseases in offspring, such as infectious and respiratory diseases, according to a study published online Aug. 5 in Pediatrics.

Abstract (http://pediatrics.aappublications.org/content/early/2013/07/31/peds.2012-3686.abstract )Full Text (subscription or payment may be required) (http://pediatrics.aappublications.org/content/early/2013/07/31/peds.2012-3686.full.pdf+html )

Age Affects Aspirin Response in Patients With Stable CAD

FRIDAY, Aug. 2 (HealthDay News) -- Age is a significant factor in determining aspirin response in patients with stable coronary artery disease (CAD), according to a study published in the July 15 issue of The American Journal of Cardiology.

Abstract (http://www.ajconline.org/article/S0002-9149(13)00818-7/abstract )Full Text (subscription or payment may be required) (http://www.ajconline.org/article/S0002-9149(13)00818-7/fulltext )

FDA Warns of Serious Skin Reactions to Acetaminophen

FRIDAY, Aug. 2 (HealthDay News) -- Acetaminophen has been linked to rare but serious skin reactions, according to a drug safety communication released by the U.S. Food and Drug Administration.

More Information (http://www.fda.gov/Safety/MedWatch/SafetyInformation/SafetyAlertsforHumanMedicalProducts/ucm363519.htm?source=govdelivery )

Dexamethasone Beats Placebo for Cancer-Related Fatigue

THURSDAY, Aug. 1 (HealthDay News) -- For patients with advanced cancer, dexamethasone is better than placebo for reducing cancer-related fatigue (CRF), according to a study published online July 29 in the Journal of Clinical Oncology.

Abstract (http://jco.ascopubs.org/content/early/2013/07/29/JCO.2012.44.4661.short )Full Text (subscription or payment may be required) (http://jco.ascopubs.org/content/early/2013/07/29/JCO.2012.44.4661.full.pdf+html )

No MI Rate Advantage for Aggressive T2DM Glucose Control

THURSDAY, Aug. 1 (HealthDay News) -- In patients with type 2 diabetes, more aggressive glucose-control strategies have variable short-term effects on microvascular complications, but they do not reduce the rate of myocardial infarction over four years of follow-up, according to a study published online July 22 in Diabetes Care.

Abstract (http://care.diabetesjournals.org/content/early/2013/07/18/dc12-2675.abstract )Full Text (subscription or payment may be required) (http://care.diabetesjournals.org/content/early/2013/07/18/dc12-2675.full.pdf+html )

Alcohol Use Down, Drug Use Up Among Pregnant Women

THURSDAY, Aug. 1 (HealthDay News) -- From 2000 to 2010 there was a decrease in alcohol abuse, but an increase in drug use, among pregnant women, according to a report published July 25 by the U.S. Substance Abuse and Mental Health Services Administration (SAMHSA).

More Information (http://www.samhsa.gov/data/spotlight/spot110-trends-pregnant-women-2013.pdf )

Mandated Mental Health Treatment Programs Save Money

THURSDAY, Aug. 1 (HealthDay News) -- Mandated, publicly-funded mental health outpatient commitment programs significantly reduce psychiatric care costs in the first two years following implementation, according to a study published online July 30 in The American Journal of Psychiatry.

Abstract (http://ajp.psychiatryonline.org/article.aspx?articleid=1722044 )Full Text (subscription or payment may be required) (http://ajp.psychiatryonline.org/article.aspx?articleid=1722044 )