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September 2013 Briefing - Pathology

September 2013 Briefing - Pathology

Here are what the editors at HealthDay consider to be the most important developments in Pathology for September 2013. This roundup includes the latest research news from journal articles, as well as the FDA approvals and regulatory changes that are the most likely to affect clinical practice.

Lower National Health Spending Due to Slow Economy

MONDAY, Sept. 30 (HealthDay News) -- National health care expenditures remain sluggish but are expected to grow at a rate of approximately 6.2 percent per year after 2014, with federal, state, and local governments accounting for half, according to research published online Sept. 18 in Health Affairs.

Abstract (http://content.healthaffairs.org/content/early/2013/09/13/hlthaff.2013.0721 )Full Text (subscription or payment may be required) (http://content.healthaffairs.org/content/early/2013/09/13/hlthaff.2013.0721.full.pdf+html )

Medicare, Medicaid Will Still Run If Government Shuts Down

MONDAY, Sept. 30 (HealthDay News) -- According to U.S. officials, veterans and Medicare and Medicaid recipients will continue to receive health care benefits even if the federal government shuts down on Tuesday.

More Information (http://www.hhs.gov/ )

Only One-Third of Voters Think Congress Should Delay ACA

MONDAY, Sept. 30 (HealthDay News) -- With a government shutdown impending, only one-third of voters think that Congress should delay, defund, or repeal the health care laws set to take effect imminently, according to a report from The Morning Consult.

More Information (http://themorningconsult.com/topline-results-september-2013-tracking-poll/ )

DOL Clarifies Employer Health Insurance Notification Duty

MONDAY, Sept. 30 (HealthDay News) -- The U.S. Department of Labor has provided clarification in the form of a frequently-asked-questions (FAQ) document, relating to employer obligations to provide employees with written notice about the Affordable Care Act's health insurance marketplaces by Oct. 1, 2013.

More Information (http://www.dol.gov/ebsa/faqs/faq-noticeofcoverageoptions.html )

Practical Tips Offered for Medical Employee Satisfaction

FRIDAY, Sept. 27 (HealthDay News) -- Managing staff is a learned skill, and one for which physicians are often ill-equipped. An article published Sept. 25 in Medical Economics lays out some practical tips and advice for motivating staff to excel.

Full Text (http://medicaleconomics.modernmedicine.com/medical-economics/news/how-physicians-can-increase-employee-satisfaction-their-medical-practice?page=0,0 )

HEALTH REFORM: ACA Impact on Medicare Recipients Unclear

FRIDAY, Sept. 27 (HealthDay News) -- The Affordable Care Act (ACA) will help millions of uninsured Americans access affordable health care coverage, but it's unclear what effect the law will have on people covered by Medicare.

More Information (https://www.healthcare.gov/ )

Mobile Apps May Expand Dermatology Practice

FRIDAY, Sept. 27 (HealthDay News) -- Mobile apps may offer an opportunity to expand delivery of dermatological care, according to research published online Sept. 25 in JAMA Dermatology.

Abstract (http://archderm.jamanetwork.com/article.aspx?articleid=1741083#Abstract )Full Text (subscription or payment may be required) (http://archderm.jamanetwork.com/article.aspx?articleid=1741083 )

Obesity Gene Testing Offers Psychological Benefit

FRIDAY, Sept. 27 (HealthDay News) -- Results from genetic testing for weight gain-related genes may offer psychological benefits beyond their limited clinical utility, according to a study published in the July issue of the Journal of Genetic Counseling.

Abstract (http://link.springer.com/article/10.1007/s10897-013-9628-9 )Full Text (subscription or payment may be required) (http://link.springer.com/article/10.1007/s10897-013-9628-9 )

HEALTH REFORM: Medicaid Expansion Will Up Coverage

THURSDAY, Sept. 26 (HealthDay News) -- Two aspects of the Affordable Care Act (ACA) have the potential to extend health insurance coverage to those who do not qualify for government-sponsored health care but cannot afford to purchase private plans.

More Information (https://www.healthcare.gov/ )

CDC: Flu Shot Coverage of Health Care Personnel Increasing

THURSDAY, Sept. 26 (HealthDay News) -- Influenza vaccination coverage has increased among health care personnel but varies by occupation type and occupational setting, according to a report published in the Sept. 27 issue of the U.S. Centers for Disease Control and Prevention's Morbidity and Mortality Weekly Report.

Full Text (http://www.cdc.gov/mmwr/preview/mmwrhtml/mm6238a2.htm?s_cid=mm6238a2_w )

No Cognitive Protective Role Seen for Omega-3 Fatty Acids

THURSDAY, Sept. 26 (HealthDay News) -- There is no evidence of a protective effect for omega-3 fatty acids on age-associated cognition or the rate of cognitive decline in older dementia-free women, according to research published online Sept. 25 in Neurology.

Abstract (http://www.neurology.org/content/early/2013/09/25/WNL.0b013e3182a9584c.abstract )Full Text (subscription or payment may be required) (http://www.neurology.org/content/early/2013/09/25/WNL.0b013e3182a9584c.full.pdf+html )

Antibiotic Protocol Selects Against Drug Resistance

THURSDAY, Sept. 26 (HealthDay News) -- Cycling between antibiotics can select against the development of drug resistance, according to a study published in the Sept. 25 issue of Science Translational Medicine.

Abstract (http://stm.sciencemag.org/content/5/204/204ra132 )Full Text (http://stm.sciencemag.org/content/5/204/204ra132.full )

Antibodies Predict Graft Injury, Loss in Kidney Transplants

WEDNESDAY, Sept. 25 (HealthDay News) -- Patients who have complement-binding donor-specific antibodies to human leukocyte antigens (HLAs) after kidney transplantation have a nearly five-fold higher risk of graft loss, according to a study published in the Sept. 26 issue of the New England Journal of Medicine.

Full Text (subscription or payment may be required) (http://www.nejm.org/doi/full/10.1056/NEJMoa1302506 )Editorial (subscription or payment may be required) (http://www.nejm.org/doi/full/10.1056/NEJMe1309686 )

HEALTH REFORM: Exchanges Offer Options for the Uninsured

WEDNESDAY, Sept. 25 (HealthDay News) -- Millions of part-time, seasonal, self-employed workers and other individuals currently without health insurance may find a solution to their vulnerable status when the new health care exchanges go into effect on Oct. 1.

More Information (https://www.healthcare.gov/ )

More Options, Lower Premiums With Insurance Exchanges

WEDNESDAY, Sept. 25 (HealthDay News) -- Consumers are likely to find insurance options more plentiful and more affordable than expected in the new Health Insurance Marketplace that goes into effect Oct. 1, according to a report released Sept. 25 by the U.S. Department of Health and Human Services.

More Information (http://www.hhs.gov/news/press/2013pres/09/20130925a.html )

C. difficile Transmitted Through Genetically Diverse Sources

WEDNESDAY, Sept. 25 (HealthDay News) -- About half of Clostridium difficile cases are genetically distinct from previous cases, suggesting that symptomatic patients are not the only source of transmission, according to a study published in the Sept. 26 issue of the New England Journal of Medicine.

Full Text (subscription or payment may be required) (http://www.nejm.org/doi/full/10.1056/NEJMoa1216064?query=featured_home )Editorial (subscription or payment may be required) (http://www.nejm.org/doi/full/10.1056/NEJMe1310454?query=featured_home )

ACP Provides Overview of Health Insurance Marketplaces

WEDNESDAY, Sept. 25 (HealthDay News) -- The opportunities and challenges presented by health care reform are discussed in an article published online Sept. 24 in the Annals of Internal Medicine.

Full Text (http://annals.org/article.aspx?articleid=1741855 )

Chronic Kidney Disease Up in the Oldest Old in the U.S.

WEDNESDAY, Sept. 25 (HealthDay News) -- The prevalence of chronic kidney disease (CKD) has increased among U.S. adults aged 80 years or older, according to research published in the Sept. 25 issue of the Journal of the American Medical Association.

Full Text (subscription or payment may be required) (http://jama.jamanetwork.com/article.aspx?articleid=1741807 )

HEALTH REFORM: Health Care Reform a Mixed Bag for Workers

TUESDAY, Sept. 24 (HealthDay News) -- Much discussion of the Affordable Care Act revolves around the dramatic changes in store for America's uninsured, but the health care reform law will also have an impact on individuals with employer-based coverage.

More Information (https://www.healthcare.gov/ )

Arsenic Exposure Ups Risk for Cardiovascular Disease

TUESDAY, Sept. 24 (HealthDay News) -- Chronic exposure to low-to-moderate levels of inorganic arsenic is associated with increased risk of cardiovascular morbidity and mortality, according to research published online Sept. 24 in the Annals of Internal Medicine.

Full Text (subscription or payment may be required) (http://annals.org/article.aspx?articleid=1740759 )Editorial (subscription or payment may be required) (http://annals.org/article.aspx?articleid=1740760 )

Marriage Shown to Provide Cancer Survival Benefit

TUESDAY, Sept. 24 (HealthDay News) -- Unmarried patients are at significantly higher risk of presentation with metastatic cancer, undertreatment, and cancer-related death, according to a study published online Sept. 23 in the Journal of Clinical Oncology.

Abstract (http://jco.ascopubs.org/content/early/2013/09/18/JCO.2013.49.6489.abstract )Full Text (http://jco.ascopubs.org/content/early/2013/09/18/JCO.2013.49.6489.full.pdf+html )Editorial (http://jco.ascopubs.org/content/early/2013/09/18/JCO.2013.51.5080.full.pdf+html )

FDA Gives Final Guidance on Mobile Medical App Oversight

TUESDAY, Sept. 24 (HealthDay News) -- The U.S. Food and Drug Administration issued final guidance for mobile application (app) developers, and is focusing its oversight on medical apps that will be used as accessories to regulated medical devices, or that transform a mobile device into a regulated medical device.

More Information (http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm369431.htm )

HEALTH REFORM: Young People Likely to Be Key to Success

MONDAY, Sept. 23 (HealthDay News) -- Young, healthy adults are considered key to the success of health insurance reform, but many are not even aware of state insurance exchanges.

More Information (https://www.healthcare.gov/ )

Infectious Endocarditis Risk ID'd in Congenital Heart Disease

MONDAY, Sept. 23 (HealthDay News) -- For children with congenital heart disease (CHD), the risk of infectious endocarditis (IE) is 6.1 per 1,000 children, and predictors include cyanotic CHD, endocardial cushion defects, and left-sided lesions, according to a study published in the Sept. 24 issue of Circulation.

Abstract (http://circ.ahajournals.org/content/128/13/1412.abstract )Full Text (http://circ.ahajournals.org/content/128/13/1412.full )Editorial (http://circ.ahajournals.org/content/128/13/1396.full )

FDA Issues Final Rule for Device Identification System

MONDAY, Sept. 23 (HealthDay News) -- The U.S. Food and Drug Administration has released a final rule for the unique device identification system (UDI) that, when implemented, will improve patient safety by providing a consistent way to identify approved medical devices.

More Information (http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm369276.htm )

Unlike Adults, No Decline Seen in MRSA Infections in Children

MONDAY, Sept. 23 (HealthDay News) -- In contrast to decreasing incidence of methicillin-resistant Staphylococcus aureus (MRSA) infection in adults, no significant reductions in health care-associated MRSA infections, and increasing incidence of community-acquired MRSA infections, have been reported in children, according to research published online Sept. 23 in Pediatrics.

Abstract (http://pediatrics.aappublications.org/content/early/2013/09/18/peds.2013-1112.abstract )Full Text (subscription or payment may be required) (http://pediatrics.aappublications.org/content/early/2013/09/18/peds.2013-1112.full.pdf+html )

Majority of U.S. Consumers Want Full Access to EMR

MONDAY, Sept. 23 (HealthDay News) -- Most U.S. consumers want to have full access to their electronic medical records (EMR), and 41 percent would be willing to switch doctors to gain access, according to a survey published by Accenture.

More Information (http://newsroom.accenture.com/news/more-than-40-percent-of-us-consumers-willing-to-switch-physicians-to-gain-online-access-to-electronic-medical-records-according-to-accenture-survey.htm?c=hls_fy13prtwt_10000108&n=smc_0713#sf17115649g )

Pap, HPV Testing Unnecessarily High in Under-21-Year-Olds

MONDAY, Sept. 23 (HealthDay News) -- For women younger than 21 years, Papanicolaou (Pap) and human papillomavirus (HPV) testing are unnecessarily high, according to a study published in the September issue of the American Journal of Obstetrics & Gynecology.

Abstract (http://www.ajog.org/article/S0002-9378(13)00547-4/abstract )Full Text (subscription or payment may be required) (http://www.ajog.org/article/S0002-9378(13)00547-4/fulltext )

HEALTH REFORM: Health Care Exchanges Going Into Effect

MONDAY, Sept. 23 (HealthDay News) -- As of Oct. 1, consumers looking for health insurance will be able to turn to state-based health care exchanges, a centerpiece of the Affordable Care Act intended to help the uninsured and small businesses find affordable coverage.

More Information (https://www.healthcare.gov/ )

PSA Testing Tied to Higher Socioeconomic Status

FRIDAY, Sept. 20 (HealthDay News) -- Prostate-specific antigen testing is more likely among affluent men, according to a study published in the October issue of The Journal of Urology.

Abstract (http://www.jurology.com/article/S0022-5347(13)04094-9/abstract )Full Text (subscription or payment may be required) (http://www.jurology.com/article/S0022-5347(13)04094-9/fulltext )

New Medicaid Enrollees Under ACA May Be Healthier

THURSDAY, Sept. 19 (HealthDay News) -- Adults potentially eligible for Medicaid under the Patient Protection and Affordable Care Act (ACA) are expected to have equal or better health status than current beneficiaries, according to research published in the September/October issue of the Annals of Family Medicine.

Abstract (http://www.annfammed.org/content/11/5/406.full )Full Text (http://www.annfammed.org/content/11/5/406.full )Editorial 1 (http://www.annfammed.org/content/11/5/402.full )Editorial 2 (http://www.annfammed.org/content/11/5/400.full )

Exposure to Tamoxifen Causes CNS Cell Death

THURSDAY, Sept. 19 (HealthDay News) -- Tamoxifen causes central nerve system (CNS) cell cytotoxicity, and MEK1/2 inhibition can prevent tamoxifen-induced cell death, according to a study published in the Sept. 18 issue of The Journal of Neuroscience.

Abstract (http://www.jneurosci.org/content/33/38/15069.abstract )Full Text (subscription or payment may be required) (http://www.jneurosci.org/content/33/38/15069.full )

Pros and Cons of Shortening Medical School Discussed

THURSDAY, Sept. 19 (HealthDay News) -- The pros and cons of shortening medical school to three years are discussed in two perspective pieces published in the Sept. 19 issue of the New England Journal of Medicine.

Full Text - Abramson (http://www.nejm.org/doi/full/10.1056/NEJMp1304681 )Full Text - Goldfarb and Morrison (http://www.nejm.org/doi/full/10.1056/NEJMp1306457 )

Millions Are Harmed by Unsafe Medical Care Each Year

THURSDAY, Sept. 19 (HealthDay News) -- Adverse events caused by inferior medical care are a major source of morbidity and mortality globally, according to research published in the October issue of BMJ Quality & Safety.

Abstract (http://qualitysafety.bmj.com/content/22/10/809.abstract )Full Text (http://qualitysafety.bmj.com/content/22/10/809.full )Editorial (http://qualitysafety.bmj.com/content/22/10/798.full )

Colorectal Cancer Screening Offers Lasting Benefits

WEDNESDAY, Sept. 18 (HealthDay News) -- Lower endoscopy and fecal occult-blood testing screening correlate with lasting reductions in colorectal cancer mortality, according to two studies published in the Sept. 19 issue of the New England Journal of Medicine.

Full Text - Nishihara (subscription or payment may be required) (http://www.nejm.org/doi/full/10.1056/NEJMoa1301969?query=featured_home )Full Text - Shaukat (subscription or payment may be required) (http://www.nejm.org/doi/full/10.1056/NEJMoa1300720?query=featured_home )Editorial (subscription or payment may be required) (http://www.nejm.org/doi/full/10.1056/NEJMe1308253?query=featured_home )

EHR Systems Meeting Meaningful Use Criteria Beneficial

WEDNESDAY, Sept. 18 (HealthDay News) -- Most electronic health record (EHR) systems meet meaningful use criteria, and these systems are associated with time-saving and other benefits, according to a September data brief published by the U.S. Centers for Disease Control and Prevention's National Center for Health Statistics.

More Information (http://www.cdc.gov/nchs/data/databriefs/db129.htm )

Unfounded Fears Prompt Prophylactic Mastectomy Choice

TUESDAY, Sept. 17 (HealthDay News) -- Among young women who undergo a bilateral mastectomy for cancer in one breast, contralateral prophylactic mastectomy (CPM) is often chosen to reduce risk of future cancer and improve survival, according to research published in the Sept. 17 issue of the Annals of Internal Medicine.

Full Text (subscription or payment may be required) (http://annals.org/article.aspx?articleid=1738492 )

High LDL Cholesterol Remains Common Among U.S. Adults

TUESDAY, Sept. 17 (HealthDay News) -- High low-density lipoprotein (LDL) cholesterol remains common among U.S. adults, according to a study published in the Sept. 1 issue of The American Journal of Cardiology.

Abstract (http://www.ajconline.org/article/S0002-9149(13)01058-8/abstract )Full Text (subscription or payment may be required) (http://www.ajconline.org/article/S0002-9149(13)01058-8/fulltext )

Telomere Length Increase Lasts With Lifestyle Intervention

TUESDAY, Sept. 17 (HealthDay News) -- For men with low-risk prostate cancer, a comprehensive lifestyle intervention is associated with increased telomere length after five years of follow-up, according to a study published online Sept. 17 in The Lancet Oncology.

Abstract (http://www.thelancet.com/journals/lanonc/article/PIIS1470-2045(13)70366-8/abstract )Full Text (subscription or payment may be required) (http://www.thelancet.com/journals/lanonc/article/PIIS1470-2045(13)70366-8/fulltext )

Livestock Industrial Agriculture Exposure Ups Odds of MRSA

TUESDAY, Sept. 17 (HealthDay News) -- Exposure to swine and dairy/veal industrial agriculture is associated with increased odds of methicillin-resistant Staphylococcus aureus (MRSA) infection; and, the incidence of health care-associated community-onset (HACO) and hospital-onset MRSA infections has decreased since 2005, according to two studies published online Sept. 16 in JAMA Internal Medicine.

Abstract - Casey (http://archinte.jamanetwork.com/article.aspx?articleid=1738717#Abstract )Full Text (subscription or payment may be required) (http://archinte.jamanetwork.com/article.aspx?articleid=1738717 )Abstract - Dantes (http://archinte.jamanetwork.com/article.aspx?articleid=1738718#Abstract )Full Text (subscription or payment may be required) (http://archinte.jamanetwork.com/article.aspx?articleid=1738718 )Editorial (subscription or payment may be required) (http://archinte.jamanetwork.com/article.aspx?articleid=1738714 )

Multiple Bilateral Circumscribed Breast Masses Usually Benign

MONDAY, Sept. 16 (HealthDay News) -- Multiple bilateral (MB) circumscribed breast masses detected with ultrasound screening are almost always benign, according to research published in the September issue of Radiology.

Abstract (http://radiology.rsna.org/content/268/3/673.abstract?sid=83bd6750-9a5a-4f05-bba2-c88853c78d69 )Full Text (subscription or payment may be required) (http://radiology.rsna.org/content/268/3/673.full )

CDC Report Sheds Light on Antibiotic-Resistant Infections

MONDAY, Sept. 16 (HealthDay News) -- Antibiotic-resistant infections claim the lives of 23,000 people in the United States every year and take a tremendous financial toll on the already overburdened health care system, according to a report issued Sept. 16 by the U.S. Centers for Disease Control and Prevention.

More Information (http://www.cdc.gov/media/releases/2013/p0916-untreatable.html )

Factors Affecting Spontaneous Clearance of Hep C Identified

MONDAY, Sept. 16 (HealthDay News) -- For individuals with acute hepatitis C virus (HCV) infection, female gender, IL28B CC genotype, and HCV genotype 1 are independently linked to spontaneous clearance, according to research published online Aug. 2 in Hepatology.

Abstract (http://onlinelibrary.wiley.com/doi/10.1002/hep.26639/abstract )Full Text (subscription or payment may be required) (http://onlinelibrary.wiley.com/doi/10.1002/hep.26639/pdf )

High Burden of Endocarditis in Older Adults

FRIDAY, Sept. 13 (HealthDay News) -- The 2007 American Heart Association guidelines recommending a restriction of antibiotic prophylaxis have not increased the rates of hospitalization or adjusted mortality for endocarditis among Medicare beneficiaries, although the burden of endocarditis is high, according to a study published online Aug. 28 in the Journal of the American College of Cardiology.

Full Text (subscription or payment may be required) (http://content.onlinejacc.org/article.aspx?articleid=1732398 )

Mediterranean Diet Tied to Less Age-Related Cognitive Decline

THURSDAY, Sept. 12 (HealthDay News) -- Greater adherence to a Mediterranean diet is associated with slower cognitive decline in older adults, according to a review published in the July issue of Epidemiology.

Abstract (http://journals.lww.com/epidem/Abstract/2013/07000/Mediterranean_Diet,_Cognitive_Function,_and.1.aspx )Full Text (subscription or payment may be required) (http://journals.lww.com/epidem/Abstract/2013/07000/Mediterranean_Diet,_Cognitive_Function,_and.1.aspx )

Whole-Body MRI Helps Predict CVD Burden in Diabetes Patients

THURSDAY, Sept. 12 (HealthDay News) -- Whole-body magnetic resonance imaging (MRI) predicts cardiac and cerebrovascular disease burden in patients with diabetes mellitus (DM), according to a study published online Sept. 10 in Radiology.

Abstract (http://radiology.rsna.org/content/early/2013/08/28/radiol.13130371.abstract )Full Text (subscription or payment may be required) (http://radiology.rsna.org/content/early/2013/08/28/radiol.13130371.full )

Maternal Opioid Use Ups Risk of Neural Tube Defects

WEDNESDAY, Sept. 11 (HealthDay News) -- A higher rate of periconceptional opioid use has been observed among mothers of infants with neural tube defects, according to research published online Sept. 6 in Obstetrics & Gynecology.

Abstract (http://journals.lww.com/greenjournal/Abstract/publishahead/Periconceptional_Use_of_Opioids_and_the_Risk_of.99689.aspx )Full Text (subscription or payment may be required) (http://journals.lww.com/greenjournal/Abstract/publishahead/Periconceptional_Use_of_Opioids_and_the_Risk_of.99689.aspx )

Measures of Glucose and its Variability Are Inter-Related

TUESDAY, Sept. 10 (HealthDay News) -- Hemoglobin A1c (HbA1c) and glycated albumin (GA) are inter-related and correlate with retinopathy and nephropathy, while only HbA1c correlates with cardiovascular disease, according to a study published online Aug. 29 in Diabetes.

Abstract (http://diabetes.diabetesjournals.org/content/early/2013/08/27/db13-0782.abstract )Full Text (subscription or payment may be required) (http://diabetes.diabetesjournals.org/content/early/2013/08/27/db13-0782.full.pdf+html )

About Half of Health Care Providers Are 'Digital Omnivores'

TUESDAY, Sept. 10 (HealthDay News) -- About half of health care providers are "digital omnivores," meaning they use a tablet, smartphone, and laptop/desktop computer routinely in a professional capacity, according to a report published by Epocrates.

More Information (http://www.epocrates.com/oldsite/statistics/2013%20Epocrates%20Mobile%20Trends%20Report_FINAL.pdf )

'Meaningful Use' Achievement Not Uniform Across Hospitals

MONDAY, Sept. 9 (HealthDay News) -- In regard to the adoption of electronic health records (EHRs), achievement of "meaningful use" criteria is not uniform across all hospitals, according to a study published in the August issue of Health Affairs.

Abstract (http://content.healthaffairs.org/content/32/8/1355?=right )Full Text (subscription or payment may be required) (http://content.healthaffairs.org/content/32/8/1355.full )

Most Physicians Report Being Satisfied With Career Choice

MONDAY, Sept. 9 (HealthDay News) -- Most physicians report being satisfied with their career choice, although 40 percent would rethink their path given the chance to choose again, according to the 2013 Great American Physician Survey published in Physicians Practice.

More Information (http://www.physicianspractice.com )

CDC: U.S. Drinking Water Sanitation Still a Concern

THURSDAY, Sept. 5 (HealthDay News) -- Sanitation and water management in the United States has improved, but potentially preventable outbreaks of drinking water-associated disease, sometimes fatal, still occur, according to a report published in the Sept. 6 issue of the U.S. Centers for Disease Control and Prevention's Morbidity and Mortality Weekly Report.

Full Text (http://www.cdc.gov/mmwr/preview/mmwrhtml/mm6235a3.htm?s_cid=mm6235a3_w )

Novel Metabolic Regulator May Benefit Obesity and Diabetes

THURSDAY, Sept. 5 (HealthDay News) -- Treatment of patients with obesity and type 2 diabetes with a variant of a recently identified metabolic regulator has favorable effects on body weight, fasting insulin, and lipid profile, but only somewhat lowers blood glucose levels, according to a study published in the Sept. 3 issue of Cell Metabolism.

Full Text (http://www.cell.com/cell-metabolism/fulltext/S1550-4131(13)00330-6 )

Animal Model of Graves' Orbitopathy Developed

THURSDAY, Sept. 5 (HealthDay News) -- A mouse model of Graves' orbitopathy, a complication of Graves' disease, has been developed that closely resembles the human condition, according to a study published in the Sept. 1 issue of Endocrinology.

Abstract (http://endo.endojournals.org/content/154/9/3008.abstract )Full Text (subscription or payment may be required) (http://endo.endojournals.org/content/154/9/3008.full )

No Link of Mediterranean Diet With Huntington's Onset

THURSDAY, Sept. 5 (HealthDay News) -- Adherence to a Mediterranean diet has no effect on the time of onset to Huntington's disease in individuals at high risk, although individual components such as high caloric intake are associated with increased risk, according to a study published online Sept. 2 in JAMA Neurology.

Abstract (http://archneur.jamanetwork.com/article.aspx?articleid=1733320#Abstract )Full Text (subscription or payment may be required) (http://archneur.jamanetwork.com/article.aspx?articleid=1733320 )

Glucagon-Induced Satiety Preserved in T1DM, Not Obesity

THURSDAY, Sept. 5 (HealthDay News) -- Glucagon increases satiety index in lean individuals and in individuals with type 1 diabetes mellitus (T1DM), but not in those with obesity, according to a study published online Aug. 21 in the Journal of Clinical Endocrinology & Metabolism.

Abstract (http://jcem.endojournals.org/content/early/2013/08/20/jc.2013-1635.abstract )Full Text (http://jcem.endojournals.org/content/early/2013/08/20/jc.2013-1635.full.pdf+html )

Raw Produce-Related 2011 Listeriosis Outbreak Investigated

THURSDAY, Sept. 5 (HealthDay News) -- The 2011 outbreak illustrated that raw produce, including cantaloupe, can be a vehicle for transmission of listeriosis, according to research published in the Sept. 5 issue of the New England Journal of Medicine.

Full Text (subscription or payment may be required) (http://www.nejm.org/doi/full/10.1056/NEJMoa1215837 )

Anti-CMV Treatment Shows Promise for Glioblastoma

WEDNESDAY, Sept. 4 (HealthDay News) -- For patients with glioblastoma, treatment with the anti-cytomegalovirus (CMV) agent valganciclovir is associated with improved survival, according to a study published in the Sept. 5 issue of the New England Journal of Medicine.

Full Text (http://www.nejm.org/doi/full/10.1056/NEJMc1302145 )

Major Health Care-Linked Infections Cost $9.8 Billion

WEDNESDAY, Sept. 4 (HealthDay News) -- The total annual cost associated with the five major health care-associated infections (HAIs) is $9.8 billion, according to a meta-analysis published online Sept. 2 in JAMA Internal Medicine.

Abstract (http://archinte.jamanetwork.com/article.aspx?articleid=1733452#Abstract )Full Text (subscription or payment may be required) (http://archinte.jamanetwork.com/article.aspx?articleid=1733452 )Editorial (subscription or payment may be required) (http://archinte.jamanetwork.com/article.aspx?articleid=1733445 )

Excess HRT-Tied Breast Cancer Risk Varies With Race, BMI

WEDNESDAY, Sept. 4 (HealthDay News) -- The increased risk of breast cancer among users of hormone replacement therapy (HRT) varies by race/ethnicity, body mass index (BMI), and breast density, according to a study published online Sept. 3 in the Journal of the National Cancer Institute.

Abstract (http://jnci.oxfordjournals.org/content/early/2013/08/26/jnci.djt207.abstract )Full Text (subscription or payment may be required) (http://jnci.oxfordjournals.org/content/early/2013/08/26/jnci.djt207.full )Editorial (subscription or payment may be required) (http://jnci.oxfordjournals.org/content/early/2013/08/26/jnci.djt239.extract )

Male-Female Physician Earnings Gap Has Persisted for 20 Years

TUESDAY, Sept. 3 (HealthDay News) -- For physicians, the male-female earnings gap has not changed significantly since 1987, according to a research letter published online Sept. 2 in JAMA Internal Medicine.

Full Text (subscription or payment may be required) (http://archinte.jamanetwork.com/article.aspx?articleid=1733450 )Editorial (subscription or payment may be required) (http://archinte.jamanetwork.com/article.aspx?articleid=1733448 )

Docs' Confidence in Diagnosis Unrelated to Diagnostic Accuracy

TUESDAY, Sept. 3 (HealthDay News) -- Physicians' confidence in their diagnostic accuracy is not associated with actual diagnostic accuracy or with case difficulty, according to a study published online Aug. 26 in JAMA Internal Medicine.

Abstract (http://archinte.jamanetwork.com/article.aspx?articleid=1731967#Abstract )Full Text (subscription or payment may be required) (http://archinte.jamanetwork.com/article.aspx?articleid=1731967 )Editorial (subscription or payment may be required) (http://archinte.jamanetwork.com/article.aspx?articleid=1731959 )

CDC: 200,000 Avoidable Deaths From Cardiovascular Disease

TUESDAY, Sept. 3 (HealthDay News) -- There were about 200,000 avoidable deaths from cardiovascular disease in 2010 in the United States, with deaths occurring disproportionately among those over 65 years old, males, non-Hispanic blacks, and those in the South, according to a report published in the Sept. 3 early-release issue of the U.S. Centers for Disease Control and Prevention's Morbidity and Mortality Weekly Report.

More Information (http://www.cdc.gov/mmwr/preview/mmwrhtml/mm62e0903a1.htm?s_cid=mm62e0903a1_w )

No Link Found Between Various Insulins and Breast Cancer

TUESDAY, Sept. 3 (HealthDay News) -- Various types of insulins are not associated with breast cancer risk, according to a study published online Aug. 15 in Diabetes Care.

Abstract (http://care.diabetesjournals.org/content/early/2013/08/12/dc13-0695.abstract )Full Text (subscription or payment may be required) (http://care.diabetesjournals.org/content/early/2013/08/12/dc13-0695.full.pdf+html )

Pre-Diagnosis Coffee Intake Tied to Prostate CA Outcomes

TUESDAY, Sept. 3 (HealthDay News) -- Higher coffee consumption before prostate cancer diagnosis is associated with a lower risk of recurrence/progression, according to a study published in the August issue of Cancer Causes & Control.

Abstract (http://link.springer.com/article/10.1007/s10552-013-0270-5 )Full Text (subscription or payment may be required) (http://link.springer.com/article/10.1007/s10552-013-0270-5 )

Employer-Based Health Insurance Premiums Rose Modestly in 2013

MONDAY, Sept. 2 (HealthDay News) -- Employer-sponsored health insurance premiums rose only modestly in 2013, according to research published in the August issue of Health Affairs.

Abstract (http://content.healthaffairs.org/content/early/2013/08/16/hlthaff.2013.0644 )Full Text (subscription or payment may be required) (http://content.healthaffairs.org/content/early/2013/08/16/hlthaff.2013.0644.full )

Workaholics Have Poorer Physical and Mental Health

MONDAY, Sept. 2 (HealthDay News) -- Workaholics, defined as those who work more than 50 hours per week, have reduced physical and mental well-being, according to researchers from Kansas State University.

Press Release (http://www.k-state.edu/media/newsreleases/aug13/workaholics82213.html )