Other Proposed Uses
Based on this supposition, products containing malic acid and other nutrients were widely offered for sale to people with fibromyalgia. However, there is as yet no evidence that these products are in fact helpful.
The body produces its own malic acid. Many fruits and vegetables also supply malic acid, most notably apples.
In studies and commercial products, the usual dose of malic acid for fibromyalgia is 1,200 to 2,800 mg per day, generally combined with magnesium and other nutrients.
Malic acid is a major ingredient in combination treatments used for fibromyalgia. However, there is no meaningful evidence that it works.
What Is the Scientific Evidence for Malic Acid?
The researchers then gave all participants the malic acid combination and increased the dose over a 6-month period. A significant improvement in fibromyalgia symptoms was found after the dose reached about 1,600 mg of malic acid with 400 mg of magnesium. However, because this part of the trial was not blinded or controlled, the results may be entirely due to the placebo effect . Only a properly designed double-blind, placebo-controlled trial of the higher malic acid dose could demonstrate that it really works, and, as yet, none have been reported.
Malic acid appears to be safe at recommended dosages. A few people reported loose stools at the higher doses in the above studies, possibly due to the magnesium in the combination.
Safety in pregnant or nursing women, children, or individuals with severe liver or kidney disease has not been established.
- Reviewer: EBSCO CAM Review Board
- Review Date: 07/2012 -
- Update Date: 07/25/2012 -