Medications for Testicular Cancer
The information provided here is meant to give you a general idea about each of the medicines listed below. Only the most general side effects are included, so ask your doctor if you need to take any special precautions.
Use each of these medicines as recommended by your doctor, or according to the instructions provided. If you have further questions about usage or side effects, contact your doctor.
Medicines may help to either prevent or reduce side effects of treatment, or to manage certain side effects once they occur. You can develop side effects from the treatment and/or from the cancer itself. Tell your doctor when you notice a new symptom, and ask him or her if any of these medicines are appropriate for you.
Prescription Medications
Antinauseants
- Prochlorperazine (Compazine)
- Odansetron (Zofran)
- Granisetron (Kytril)
- Metoclopramide (eg, Octamide, Metoclopramide Intensol, Reglan)
Corticosteroids
- Dexamethasone (eg, Cortastat, Dalalone, Decadrol)
- Prednisone (eg, Cordrol, Deltasone, Liquid Pred)
Painkillers—Narcotics
- Hydrocodone (eg, Dilaudid, Hydrostat)
- Methadone (eg, Astramorph PF, Duramorph, Kadian)
- Oxycodone and acetaminophen (Percocet)
Over-the-Counter Medications
Prescription Medications
Antinauseants
Common names include:
- Prochlorperazine (Compazine)
- Odansetron (Zofran)
- Granisetron (Kytril)
- Metoclopramide (eg, Octamide, Metoclopramide Intensol, Reglan)
Antinauseants, also called anti-emetics, are given to help treat nausea and vomiting that may be caused by chemotherapy, radiation, or surgery to treat cancer. Prochlorperazine can be taken by mouth, injection, or a suppository. Ondansetron and granisetron can be taken orally or as injections; metoclopramide is usually given by injection.
Side effects may include:
For prochlorperazine:
- Blurred vision, change in color vision, or difficulty seeing at night
- Fainting
- Loss of balance control
- Restlessness or need to keep moving
- Shuffling walk
- Stiffness of arms or legs
- Trembling and shaking of hands and fingers
For odansetron:
- Constipation
- Diarrhea
- Fever
- Headache
For granisetron:
- Abdominal pain
- Constipation
- Diarrhea
- Headache
- Unusual tiredness or weakness
For metoclopramide:
- Diarrhea (with high doses)
- Drowsiness
- Restlessness
- Increased risk of tardive dyskinesia (a serious neurological condition) in patients who take metoclopramide for longer than three months
Corticosteroids
Common names include:
- Dexamethasone (eg, Cortastat, Dalalone, Decadrol)
- Prednisone (eg, Cordrol, Deltasone, Liquid Pred)
Corticosteroids help to minimize inflammation and to relieve pain due to inflammation. You may experience pain and inflammation for a variety of reasons, such as:
- Bone pain from cancer that has spread to your bones
- Edema (fluid build-up in cells) caused by tumors or treatment
Common side effects include:
- Increased appetite
- Indigestion
- Nervousness or restlessness
Painkillers—Narcotics
Common names include:
- Hydrocodone (eg, Dilaudid, Hydrostat)
- Methadone (eg, Astramorph PF, Duramorph, Kadian)
- Oxycodone and acetaminophen (Percocet)
Narcotics act on the central nervous system to relieve pain. These drugs can be very effective, however they must be used with great caution because they can be mentally and/or physically addicting. If you are going to take one of these drugs for a long period of time, your doctor will closely monitor you.
Percocet is a combination medicine. A narcotic analgesic and acetaminophen used together may provide better pain relief than either medicine used alone. And in some cases, lower doses of each medicine are necessary to achieve pain relief.
The most common side effects of narcotics include:
- Dizziness, light-headedness, or feeling faint
- Drowsiness
- Nausea or vomiting
Blood Stem Cell Support Drugs
Common names include:
- Filgrastim (Neupogen)
- Epoetin (Epogen, Procrit)
During cancer treatment, blood cells can be destroyed along with cancer cells. Filgrastim helps your bone marrow make new white blood cells, which help your body fight infection. Therefore, filgrastim helps to reduce your risk of infection.
Epoetin helps your bone marrow to make new red blood cells. Low red blood cell levels can lead to
anemia
; therefore, epoetin helps reduce your risk of anemia. Epoetin is quite effective, but it has a two-week delay between the injection and when your red blood cell count really starts to come back. It is not used as a “quick fix” for a low red blood cell count; a blood transfusion is usually performed if you need to recover your red blood cell count more quickly.
Both filgrastim and epoetin are given by injection in your doctor's office.
Common side effects include:
For filgrastim:
- Headache
- Pain in arms or legs
- Pain in joints or muscles
- Pain in lower back or pelvis
- Skin rash or itching
For epoetin:
- Cough, sneezing, or sore throat
- Fever
- Swelling of face, fingers, ankles, feet, or lower legs
- Weight gain
Over-the-Counter Medications
Nonsteroidal Anti-inflammatory Drugs (NSAIDs)
Common names include:
- Ibuprofen (eg, Advil)
- Naproxen (eg, Aleve)
NSAIDs are used to relieve pain and inflammation. You may experience pain and inflammation for a variety of reasons, such as:
- Bone pain from cancer that has spread to your bones
- Edema (fluid build-up in cells) caused by tumors or treatment
Common side effects include:
- Stomach cramps, pain, or discomfort
- Dizziness, drowsiness, or lightheadedness
- Headache
- Heartburn , indigestion, nausea, or vomiting
Special Considerations
If you are taking medicines, follow these general guidelines:
- Take your medicine as directed. Do not change the amount or the schedule.
- Do not stop taking them without talking to your doctor.
- Do not share them.
- Know what the results and side effects. Report them to your doctor.
- Some drugs can be dangerous when mixed. Talk to a doctor or pharmacist if you are taking more than one drug. This includes over-the-counter medicine and herb or dietary supplements.
- Plan ahead for refills so you don’t run out.
References
Casciato DA. Manual of Clinical Oncology. 5th ed. Philadelphia, PA: Lippincott Williams & Wilkins; 2004.
Cashen AF, Wildes TM. The Washington Manual of Hematology and Oncology Subspeciality Consult. 2nd ed. Philadelphia, PA: Wolter Kluwers Health; 2008.
FDA's MedWatch safety alerts: March 2009. US Food and Drug Administration website. Available at: http://www.fda.gov/ForConsumers/ConsumerUpdates/ucm142815.htm . Published March 23, 2009. Accessed August 4, 2009.
National Cancer Institute website. Available at: http://www.cancer.gov . Accessed January 31, 2006.
United States Pharmacopeial Convention. USP DI. 21st ed. Englewood, CO: Micromedex; 2001.